| Project/Area Number |
26860217
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nara Medical University |
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Principal Investigator |
Kyotani Yoji 奈良県立医科大学, 医学部, 助教 (10706534)
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| Research Collaborator |
TAKASAWA Shin
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | Obstructive sleep apnea / vascular smooth muscle / epiregulin / interleukin-6 / インターロイキン-6 / 間歇的低酸素 / 睡眠時無呼吸症候群 / 間歇的低酸素症 / 血管平滑筋細胞 |
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| Outline of Final Research Achievements |
Sleep apnea (SA) is characterized by intermittent hypoxia (IH) and a risk factor for atherosclerosis which consequently cause myocardial infarction (MI). We finally aim to discover the prophylaxis against MI and previously found out that IH induced a increase of epiregulin which had a relation to atherosclerosis. However, its underlying mechanisms have been remained. In this study, we show that the proinflammatory cytokine IL-6 might be involved in the IH-induced increase of epiregulin. IL-6 has a relation to several inflammatory diseases and may play a pivotal role in the progression of MI and inflammatory diseases including autoimmune disease in patients with SA. IL-6 and its increase in IH may be an important for the establish of prophylaxis.
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