Imputation-based genome-wide association study of sarcoidosis

• Project/Area Number: 26860226
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human genetics
• Research Institution: Yokohama City University
• Principal Investigator: MEGURO Akira 横浜市立大学, 医学(系)研究科(研究院), 特任講師 (60508802)
• Research Collaborator: MIZUKI Nobuhisa ; OHNO Shigeaki ; PETREK Martin ; KASTNER Dan ; NANBA Reiko ; SATO Mayuki
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: サルコイドーシス / 遺伝子 / GWAS / imputation

Outline of Final Research Achievements

Sarcoidosis is a chronic multi-systemic inflammatory disorder. In this study, to identify new susceptibility genes of sarcoidosis, we performed an imputation-based genome-wide association study (GWAS) of sarcoidosis using a Japanese population. After the imputed GWAS stage, we performed a replication study using independent Japanese and Czech populations. This study found some new susceptibility genes of sarcoidosis.

Research Products

• [Int'l Joint Research] パラッキー大学(チェコ)
• [Int'l Joint Research] アメリカ国立衛生研究所(米国)
• [Journal Article] Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia. (2015)
  • Author(s): Miyake M, Yamashiro K, Tabara Y, Suda K, Morooka S, Nakanishi H, Khor CC, Chen P, Qiao F, Nakata I, Akagi-Kurashige Y, Gotoh N, Tsujikawa A, Meguro A, Kusuhara S, Polasek O, Hayward C, Wright AF, Campbell H, Mizuki N, et al
  • Journal Title: Nat Commun Volume: 印刷中 Issue: 1 Pages: 6689-6689
  • DOI: 10.1038/ncomms7689
  • Peer Reviewed / Open Access
• [Journal Article] Identification of possible pathogenic pathways in Behçet's disease using genome-wide association study data from two different populations. (2015)
  • Author(s): Bakir-Gungor B, Remmers EF, Meguro A, Mizuki N, Kastner DL, Gul A, Sezerman OU
  • Journal Title: Eur J Hum Genet Volume: 23(5) Issue: 5 Pages: 678-687
  • DOI: 10.1038/ejhg.2014.158
  • Peer Reviewed