• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Modification of estrogen action of breast cancer by tumor-associated immune cells

Research Project

Project/Area Number 26860229
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionTohoku University

Principal Investigator

TAKAGI Kiyoshi  東北大学, 医学(系)研究科(研究院), 助教 (80595562)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords乳癌 / マクロファージ / 腫瘍免疫
Outline of Final Research Achievements

Immunohistochemical analysis revealed that infiltrating macrophages were associated with more aggresive phenotype of estrogen receptor-positive breast carcinomas. Generally, macrophages are divided into M1 and M2 macrophages based on molecular markers, and most of intratumoral macrophages are M2. Coculture of MCF-7 breast caancer cells and M2-polarized THP-1 and U937 leukemic cells demonstrated that M2 macrophages enhanced migration property of breast cancer cells, while expression of estrogern recetor and estrogen-responsive genes was down-reglated in breast cancer cells.
These fndings may suggest taht breast cancer cells acquires more aggressive phenotype by interaction with M2macrophages, and lose estrogen-dependency. Therfore, it is speculated that M2 macrophages are possibly asspciated with resistance to endocrine therapy of estrogen-sensitive breast cancer and therefore M2 macrophages are considered potent therapeutic target of breast carcinomas.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (26 results)

All 2016 2015 2014

All Journal Article (9 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 9 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (16 results) Book (1 results)

  • [Journal Article] Nucleobindin 2 (NUCB2) in human endometrial carcinoma: a potent prognostic factor associated with cell proliferation and migration2016

    • Author(s)
      Takagi K, Miki Y, Tanaka S, Hashimoto C, Watanabe M, Sasano H, Ito K, Suzuki T
    • Journal Title

      Endocrine Journal

      Volume: 63 Issue: 3 Pages: 287-299

    • DOI

      10.1507/endocrj.EJ15-0490

    • NAID

      130005140784

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] KLF15 in breast cancer: a novel tumor suppressor?2015

    • Author(s)
      Yoda T, McNamara KM, Miki Y, Onodera Y, Takagi K, Nakamura Y, Ishida T, Suzuki T, Ohuchi N, Sasano H.
    • Journal Title

      Cell Oncol (Dordr).

      Volume: 38(3) Issue: 3 Pages: 227-235

    • DOI

      10.1007/s13402-015-0226-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 11β-Prostaglandin F2α, a bioactive metabolite catalyzed by AKR1C3, stimulates Prostaglandin F receptor and induces Slug expression in breast cancer.2015

    • Author(s)
      Yoda T, Kikuchi K, Miki Y, Onodera Y, Hata S, Takagi K, Nakamura Y, Hirakawa H, Ishida T, Suzuki T, Ohuchi N, Sasano H, McNamara KM.
    • Journal Title

      Mol Cell Endocrinol.

      Volume: 413 Pages: 236-247

    • DOI

      10.1016/j.mce.2015.07.008

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TET2 repression by androgen hormone regulates global hydroxymethylation status and prostate cancer progression.2015

    • Author(s)
      Takayama K, Misawa A, Suzuki T, Takagi K, Hayashizaki Y, Fujimura T, Homma Y, Takahashi S, Urano T, Inoue S
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 8219-8219

    • DOI

      10.1038/ncomms9219

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Abnormal expression of miR-1 in breast carcinoma as a potent prognostic factor.2015

    • Author(s)
      Minemura H, Takagi K, Miki Y, Shibahara Y, Nakagawa S, Ebata A, Watanabe M, Ishida T, Sasano H, Suzuki T.
    • Journal Title

      Cancer Sci.

      Volume: 106(11) Issue: 11 Pages: 1642-1650

    • DOI

      10.1111/cas.12808

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Immunolocalization of thymidylate synthase as a favorable prognostic marker in estrogen receptor-positive breast carcinoma2015

    • Author(s)
      Kiyoshi Takagi, Yasuhiro Miki, Yasuhiro Nakamura, Hisashi Hirakawa, Yoichiro Kakugawa, Goro Amano, Mika Watanabe, Takanori Ishida, Hironobu Sasano and Takashi Suzuki
    • Journal Title

      HISTOLOGY AND HISTOPATHOLOGY

      Volume: in press

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] The role of 5α-reductase type 1 associated with intratumoral dihydrotestosterone concentrations in human endometrial carcinoma.2015

    • Author(s)
      Tanaka S, Miki Y, Hashimoto C, Takagi K, Doe Z, Li B, Yaegashi N, Suzuki T, Ito K.
    • Journal Title

      Mol Cell Endocrinol.

      Volume: 401 Pages: 56-64

    • DOI

      10.1016/j.mce.2014.11.022

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex.2014

    • Author(s)
      Yokoyama A, Igarashi K, Sato T, Takagi K, Otsuka I M, Shishido Y, Baba T, Ito R, Kanno J, Ohkawa Y, Morohashi K, Sugawara A.
    • Journal Title

      J Biol Chem.

      Volume: 289 Issue: 26 Pages: 18152-18162

    • DOI

      10.1074/jbc.m114.566448

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunolocalization of corticotropin-releasing hormone (CRH) and its receptors (CRHR1 and CRHR2) in human endometrial carcinoma: CRHR1 as a potent prognostic factor.2014

    • Author(s)
      Sato N, Takagi K, Suzuki T, Miki Y, Tanaka S, Nagase S, Warita H, Fukudo S, Sato F, Sasano H, Ito K.
    • Journal Title

      Int J Gynecol Cancer

      Volume: 24 Issue: 9 Pages: 1549-1557

    • DOI

      10.1097/igc.0000000000000269

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 膵癌組織におけるCRH発現と生存予後の関連2015

    • Author(s)
      佐藤菜保子、片寄友、川口桂、大塚英郎、森川孝則、中川圭、元井冬彦、内藤剛、高木清司、鈴木貴、福土審、佐藤冨美子、海野倫明
    • Organizer
      第53回 日本癌治療学会誌
    • Place of Presentation
      京都(国立京都国際会館)
    • Year and Date
      2015-10-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Hexokinase II in human colorectal cancer as a potent prognostic predictor2015

    • Author(s)
      片桐宗利、鈴木貴、唐澤秀明、高木清司、前田晋平、元井冬彦、内藤剛、海野倫明
    • Organizer
      第74回 日本癌学会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effects of relaxin on endometrial cancer cell proliferation and invasion through differential pathways2015

    • Author(s)
      笛未崎、三木康宏、高木清司、鈴木貴、伊藤潔
    • Organizer
      第74回 日本癌学会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Involvement of stress hormone, cortisol in endometrial cancer progression2015

    • Author(s)
      三木康宏、笛未崎、高木清司、鈴木貴、笹野公伸、伊藤潔
    • Organizer
      第74回 日本癌学会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Abnormal expression of miR-1 in breast carcinoma as apotent prognostic factor2015

    • Author(s)
      峯村洋行、高木清司、三木康宏、柴原裕紀子、中川紗紀、江幡明子、渡辺みか、石田孝宣、笹野公伸、鈴木貴
    • Organizer
      第74回 日本癌学会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] Immunolocalization of CITED2 in human breast carcinoma: a potent prognostic factor2015

    • Author(s)
      高木清司、峯村洋行、三木康宏、高橋光、中村保宏、石田孝宣、笹野公伸、鈴木貴
    • Organizer
      第74回 日本癌学会
    • Place of Presentation
      名古屋(名古屋国際会議場)
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] 乳癌微小環境における癌と脂肪細胞の相互作用に関与するLCN2の役割2015

    • Author(s)
      櫻井美奈子、河原由依、三木康宏、高木清司、鈴木貴、石田孝宜、大内憲明、笹野公伸
    • Organizer
      第88回 日本内分泌学会
    • Place of Presentation
      東京(ホテルニューオータニ東京)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Annual Research Report
  • [Presentation] S100A7 in breast carcinoma invasion into adipose tissue2014

    • Author(s)
      Minako Sakurai, Yasuhiro Miki, Kiyoshi Takagi, Takashi Suzuki, Hironobu Sasano
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] 11β-prostaglandin F2α produced by AKR1C3 stimulates FP-receptor and contributes to breast cancer progression2014

    • Author(s)
      Tomomi Yoda, Keely MMcNamara, Yasuhiro Miki, Kiyoshi Takagi, Takashi Suzuki, Hironobu Sasano
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Transforming acidic coiled-coil-containing protein 2 (Tacc2) immunolocalization in breast carcinoma2014

    • Author(s)
      Yoshiaki Onodera, Kiyoshi Takagi, Yasuhiro Miki, Yasuhiro Nakamura, Mika Watanabe, Takanori Ishida, Hironobu Sasano, Satoshi Inoue, Takashi Suzuki
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] NUCB2 in human endometrial carcinoma as a potent prognostic factor2014

    • Author(s)
      Kiyoshi Takagi, Yasuhiro Miki, Sota Tanaka, Nobuo Yaegashi, Hironobu Sasano, Kiyoshi Ito, Takashi Suzuki
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] p62/sequestosome 1 is asn independent prognostic factor and promotes cell proliferation in human colorectal carcinoma2014

    • Author(s)
      Shun Nakayama, Takashi Suzuki, Shinichi Yabuuchi, Kiyoshi Takagi, Yoshiaki Onodera, Yasuhiro Nakamura, Mika Watanabe, Hiroshi Yoshida, Takanori Morikawa, Hideaki Karasawa, Takeshi Naito, Michiaki Unno, Hironobu Sasano
    • Organizer
      日本癌学会学術総会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report
  • [Presentation] Tumor suppressive roles of ARHGAP15 in human breast cancer2014

    • Author(s)
      Kiyoshi Takagi, Yasuhiro Miki, Yoshiaki Onodera, Yasuhiro Nakamura, Takanori Ishida, Hironobu Sasano and Takashi Suzuki
    • Organizer
      ICE/ENDO 2014
    • Place of Presentation
      シカゴ(アメリカ)
    • Year and Date
      2014-06-21 – 2014-06-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 11β-Prostaglangin F2α Produced By AKP1C3 Stimulates FP-Receptor and Contributes to Breast Cancer Progression2014

    • Author(s)
      Tomomi Yoda, Keely MMcNamara, Yasuhiro Miki, Kiyoshi Takagi, Takanori Ishida, Takashi Suzuki, Noriaki Ohuchi, Hironobu Sasano
    • Organizer
      ICE/ENDO 2014
    • Place of Presentation
      シカゴ(アメリカ)
    • Year and Date
      2014-06-21 – 2014-06-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Identification of Signaling Factors Involved in an Interaction Between Human Breast Carcinoma and Adipocytes2014

    • Author(s)
      Minako Sakurai, Yasuhiro Miki, Kiyoshi Takagi, Takashi Suzuki, Hironobu Sasano
    • Organizer
      ICE/ENDO 2014
    • Place of Presentation
      シカゴ(アメリカ)
    • Year and Date
      2014-06-21 – 2014-06-24
    • Related Report
      2014 Research-status Report
  • [Presentation] Intratumoral Concentration of Stress Hormone, Cortisol in Endometrial Carcinoma2014

    • Author(s)
      Yasuhiro Miki, Kiyoshi Takagi, Zhulanqiqige Doe, Sota Tanaka, Takashi Suzuki, Hironobu Sasano, Kiyoshi Ito
    • Organizer
      ICE/ENDO 2014
    • Place of Presentation
      シカゴ(アメリカ)
    • Year and Date
      2014-06-21 – 2014-06-24
    • Related Report
      2014 Research-status Report
  • [Book] 医学のあゆみ2015

    • Author(s)
      鈴木貴、高木清司
    • Total Pages
      2
    • Publisher
      医歯薬出版
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi