| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
Cerebral amyloid angiopathy (CAA) characterized by deposition of amyloid β protein in the vessel walls in the central nervous system rarely develops inflammation and/or vasculitis (CAA-related inflammation). Although CAA is commonly observed in elder people, details of the pathomechanisms of CAA-related inflammation are still uncertain. In this study, I have collected samples from the patients with CAA and CAA-related inflammation throughout Japan, such as cerebrospinal fluid, brain tissue, and DNA. Cerebrospinal fluid samples in patients with CAA-related inflammation demonstrated alteration of inflammatory cytokines. These data disclosed pathomechanisms of CAA-related inflammation.
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