Pathomechanisms of cerebral amyloid angiopathy-related inflammation
Project/Area Number |
26860234
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Human pathology
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Research Institution | Kanazawa University |
Principal Investigator |
Sakai Kenji 金沢大学, 附属病院, 助教 (00572306)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 脳アミロイドアンギオパチー / 炎症 / 遺伝子多型 |
Outline of Final Research Achievements |
Cerebral amyloid angiopathy (CAA) characterized by deposition of amyloid β protein in the vessel walls in the central nervous system rarely develops inflammation and/or vasculitis (CAA-related inflammation). Although CAA is commonly observed in elder people, details of the pathomechanisms of CAA-related inflammation are still uncertain. In this study, I have collected samples from the patients with CAA and CAA-related inflammation throughout Japan, such as cerebrospinal fluid, brain tissue, and DNA. Cerebrospinal fluid samples in patients with CAA-related inflammation demonstrated alteration of inflammatory cytokines. These data disclosed pathomechanisms of CAA-related inflammation.
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Report
(4 results)
Research Products
(7 results)
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[Journal Article] Significant association of cadaveric dura mater grafting with subpial Aβ deposition and meningeal amyloid angiopathy.2016
Author(s)
Hamaguchi T, Taniguchi Y, Sakai K, Kitamoto T, Takao M, Murayama S, Iwasaki Y, Yoshida M, Shimizu H, Kakita A, Takahashi H, Suzuki H, Naiki H, Sanjo N, Mizusawa H, Yamada M.
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Journal Title
Acta Neuropathol.
Volume: 132(2)
Issue: 2
Pages: 313-5
DOI
Related Report
Peer Reviewed / Open Access
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