Analysis of pathogenesis using NGS in Merkel cell carcinoma associated polyomavirus
Project/Area Number |
26860238
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Human pathology
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Research Institution | Tottori University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | メルケル細胞癌 / MCPyV / Immunohistochemistry / CADM1 / Hedgehog signal経路 / JAK-STAT経路 / immunohistochemistry / NGS |
Outline of Final Research Achievements |
Merkel cell carcinoma (MCC) is a malignant neuroendocrine skin tumor that occurs most often in elderly patients. Approximately 80% of MCCs harbor Merkel cell polyomavirus (MCPyV), thought to be a carcinogenic agent. In this study, MCPyV-negative MCCs significantly expressed higher CADM1 and lower MAL than MCPyV-positive MCCs and related to unfavorable outcomes in MCCs. In hedgehog signaling pathway, increased SHH and GLI1 expression was associated with better prognosis. JAK-STAT signaling pathway was expressed in MCCs. Therefore, we suggest that these factors may play a important role in tumorigenesis of MCCs.
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Report
(4 results)
Research Products
(12 results)
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[Presentation] Ecology of merkel cell polyomavirus in healthy skin among individuals in an asian cohort shows close agreement with interleukin-1 loop model in langerhans cell histiocytosis.2016
Author(s)
Murakami I, Nakashima J, Hashida Y, Daibata M, Matsushita M, Iwasaki T, Kuwamoto S, Kato M, Nagata K, Hayashi K, Oka T, Yoshino T, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F.
Organizer
32nd Annual Meeting of the Histiocyte Society
Place of Presentation
Dublin (Ireland)
Year and Date
2016-10-17
Related Report
Int'l Joint Research
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[Presentation] Expression of a long non-coding RNA NEAT1 is significantly higher in MCPyV-positive Merkel cell carcinomas than MCPyV-negative ones.2016
Author(s)
Akizuki G, Imamura K, Yamada T, Mizutani R, Matsushita M, Iwasaki T, Nonaka D, Kuwamoto S, Nagata K, Hayashi K, Akimitsu N.
Organizer
XXXI International Congress of the International Academy of Pathology and 28th Congress of the European Society of Pathology
Place of Presentation
Cologne (Germany)
Year and Date
2016-09-25
Related Report
Int'l Joint Research
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