Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Outline of Final Research Achievements |
Merkel cell carcinoma (MCC) is a malignant neuroendocrine skin tumor that occurs most often in elderly patients. Approximately 80% of MCCs harbor Merkel cell polyomavirus (MCPyV), thought to be a carcinogenic agent. In this study, MCPyV-negative MCCs significantly expressed higher CADM1 and lower MAL than MCPyV-positive MCCs and related to unfavorable outcomes in MCCs. In hedgehog signaling pathway, increased SHH and GLI1 expression was associated with better prognosis. JAK-STAT signaling pathway was expressed in MCCs. Therefore, we suggest that these factors may play a important role in tumorigenesis of MCCs.
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