Expression of miRNAs predicting lymph node metastasis in early dolorectal carcinoma

• Project/Area Number: 26860240
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Yokohama City University
• Principal Investigator: TATEISHI Yoko 横浜市立大学, 医学部, 助教 (20644438)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 早期大腸癌 / リンパ節転移 / microRNA / early colon cancer / lymph node metastasis

Outline of Final Research Achievements

Lymph node metastasis occurs in about 10% of patients with submucosal invasive colorectal carcinoma. We foused on the submucosal invasive carcinoma and examined the expression of microRNAs to delineate its relationship with clinicopathological features. We reported that the expression of miR-31 was higher in colorectal cancer tissue than in non-tumoral tissue. The up-regulated expression of miR-31 may play an oncogenic role in the early stage of carcinogenesis in colorectal cancers.

Research Products

• [Journal Article] The potential role of microRNA-31 expression in early colorectal cancer (2015)
  • Author(s): Tateishi Y
  • Journal Title: Pathology International Volume: 65(10) Issue: 10 Pages: 513-518
  • DOI: 10.1111/pin.12334
  • Peer Reviewed
• [Presentation] 早期大腸がんにおけるmiroRNAの発現 (2015)
  • Author(s): 立石陽子
  • Organizer: 第74回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-10-08
• [Presentation] Exprssion of oncogenic modulator miR-31 and miR-21 are up-regulated in early CRC (2014)
  • Author(s): 立石陽子、奥寺康司、三井秀昭、梅田茂明、渡辺一輝、河野尚美、稲山嘉明、大橋健一
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 早期大腸癌手術症例におけるmicroRNA発現と悪性度の関連 (2014)
  • Author(s): 立石陽子、奥寺康司、三井秀昭、梅田茂明、河野尚美、大橋健一
  • Organizer: 第103回日本病理学会総会
  • Place of Presentation: 広島国際会議場(広島県広島市)
  • Year and Date: 2014-04-24 – 2014-04-26
• [Remarks] 横浜市立大学病態病理学教室 消化管がんの発生・進展
  • URL: http://www-user.yokohama-cu.ac.jp/~pathola/custom13.html