Expression of miRNAs predicting lymph node metastasis in early dolorectal carcinoma
| Project/Area Number |
26860240
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Yokohama City University |
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Principal Investigator |
TATEISHI Yoko 横浜市立大学, 医学部, 助教 (20644438)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 早期大腸癌 / リンパ節転移 / microRNA / early colon cancer / lymph node metastasis |
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| Outline of Final Research Achievements |
Lymph node metastasis occurs in about 10% of patients with submucosal invasive colorectal carcinoma. We foused on the submucosal invasive carcinoma and examined the expression of microRNAs to delineate its relationship with clinicopathological features. We reported that the expression of miR-31 was higher in colorectal cancer tissue than in non-tumoral tissue. The up-regulated expression of miR-31 may play an oncogenic role in the early stage of carcinogenesis in colorectal cancers.
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Report
(3 results)
Research Products
(5 results)
