| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The study focuses on primary cilia, which is one of the cellular organelles and can be formed in pancreatic cancer cells. Pancreatic cancer with primary cilia is recently recognized as a high-grade one, however, the mechanism is unclear. In this study, we clarify that IFT88 and KIF3A, which are necessary to form primary cilia, are related to colony formation in vitro and tumor formation in vivo.
These results reflect the character of pancreatic cancer with primary cilia; relatively well-differentiated morphology and the high ability of lymph node metastases. Our results are expected to contribute to analysis of the aggressiveness and the exploitation of novel therapeutic targets for pancreatic cancer.
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