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The significance of primary cilia in pancreatic cancer

Research Project

Project/Area Number 26860246
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionKeio University

Principal Investigator

Emoto Katsura  慶應義塾大学, 医学部(信濃町), 助教 (40570859)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsprimary cilia / 膵癌 / 悪性度 / 腫瘍形成能 / 細胞株 / RNAi / 癌細胞株 / 膵がん / Primary cilia / 病理学 / 人体病理学
Outline of Final Research Achievements

The study focuses on primary cilia, which is one of the cellular organelles and can be formed in pancreatic cancer cells. Pancreatic cancer with primary cilia is recently recognized as a high-grade one, however, the mechanism is unclear. In this study, we clarify that IFT88 and KIF3A, which are necessary to form primary cilia, are related to colony formation in vitro and tumor formation in vivo.
These results reflect the character of pancreatic cancer with primary cilia; relatively well-differentiated morphology and the high ability of lymph node metastases. Our results are expected to contribute to analysis of the aggressiveness and the exploitation of novel therapeutic targets for pancreatic cancer.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (2 results)

  • [Journal Article] Upregulated SMAD3 promotes epithelial-mesenchymal transition and predicts poor prognosis in pancreatic ductal adenocarcinoma2014

    • Author(s)
      Yamazaki K, Masugi Y, Effendi K, Tsujikawa H, Hiraoka N, Kitago M, Shinoda M, Itano O, Tanabe M, Kitagawa Y, Sakamoto M
    • Journal Title

      Laboratory investigation

      Volume: 印刷中 Issue: 4 Pages: 817-25

    • DOI

      10.1016/j.humpath.2013.11.017

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 膵がん細胞に形成されるPrimary ciliaの臨床的意義と膵がん細胞株を用いたin vitro/in vivoでの解析2016

    • Author(s)
      江本 桂
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] Presence of primary cilia in cancer cells correlates with prognosis of pancreatic ductal adenocarcinoma2014

    • Author(s)
      Katsura Emoto, Yohei Masugi, Ken Yamazaki, Kathryn Effendi, Hanako Tsujikawa, Minoru Kitago, Osamu Itano, Yuko Kitagawa, and Michiie Sakamoto
    • Organizer
      AACR Annual Meeting 2014
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2014-04-05 – 2014-04-09
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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