| Project/Area Number |
26860249
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Human pathology
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| Research Institution | Tokai University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 膵神経内分泌腫瘍 / Nectin / Necl / 膵臓 / 神経内分泌腫瘍 / 膵管癌 / Nectin-3 / 上皮間葉転換 / 細胞接着 |
|---|
| Outline of Final Research Achievements |
Nectin expression in pancreatic neuroendocrine neoplasms (PNENs) was evaluated by immunohistochemistry and the role of nectin-3 in pancreatic cancer cell lines was analyzed. Immunohistochemical analysis revealed that nectin-2 and nectin-3 showed relatively high expression in PNENs, whereas nectin-1 and nectin-4 showed no or low expression. The low expression of nectin-3 in PNENs was associated with non-functional tumors, larger tumor size, higher Ki-67 labeling index, and a higher WHO grade. Moreover, nectin-3-knockdown pancreatic cancer cells exhibited a faster cell proliferation rate and migration than the negative control cells, although no significant difference was detected in the invasion assay.
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