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Expression and role of nectin/necl in pancreatic neuroendocrine neoplasms

Research Project

Project/Area Number 26860249
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Human pathology
Research InstitutionTokai University

Principal Investigator

HIRABAYASHI Kenichi  東海大学, 医学部, 講師 (60514388)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords膵神経内分泌腫瘍 / Nectin / Necl / 膵臓 / 神経内分泌腫瘍 / 膵管癌 / Nectin-3 / 上皮間葉転換 / 細胞接着
Outline of Final Research Achievements

Nectin expression in pancreatic neuroendocrine neoplasms (PNENs) was evaluated by immunohistochemistry and the role of nectin-3 in pancreatic cancer cell lines was analyzed. Immunohistochemical analysis revealed that nectin-2 and nectin-3 showed relatively high expression in PNENs, whereas nectin-1 and nectin-4 showed no or low expression. The low expression of nectin-3 in PNENs was associated with non-functional tumors, larger tumor size, higher Ki-67 labeling index, and a higher WHO grade. Moreover, nectin-3-knockdown pancreatic cancer cells exhibited a faster cell proliferation rate and migration than the negative control cells, although no significant difference was detected in the invasion assay.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2015

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results)

  • [Journal Article] Nectin expression in pancreatic adenocarcinoma: nectin-3 is associated with a poor prognosis2015

    • Author(s)
      Izumi, H. Hirabayashi, K. Nakamura, N. Nakagohri, T.
    • Journal Title

      Surgery Today

      Volume: 45 Issue: 4 Pages: 487-494

    • DOI

      10.1007/s00595-015-1126-2

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 浸潤性膵管癌におけるnectin-1発現の検討2015

    • Author(s)
      平林, 健一 山田, 美鈴 丸野, 敦子 和泉, 秀樹 中郡, 聡夫 峯, 徹哉 中村, 直哉
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-05-02
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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