Clarification of mechanism in induction of DNA methylation using Epstein-Barr virus infection experiment
Project/Area Number |
26860257
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Experimental pathology
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Research Institution | Chiba University |
Principal Investigator |
Matsusaka Keisuke 千葉大学, 医学(系)研究科(研究院), 助教 (40610150)
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | エピジェネティクス / 胃癌 / Epstein-Barr virus |
Outline of Final Research Achievements |
Genome-wide DNA methylation analysis in early phase of Epstein-Barr virus infection revealed how aberrant DNA methylation could be induced around transcription start sites (TSSs) or in genebody and intergenic regions. DNA methylation occurred from the CpG shore or shelves to CpG islands. In expression analysis by RNA-sequencing, dynamic expression alteration of both host cells and EBV could be observed. These findings should be significant clues to elucidate the mechanisms of induction of aberrant DNA methylation.
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Report
(3 results)
Research Products
(11 results)
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[Journal Article] Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway.2016
Author(s)
Sakai E, Fukuyo M, Ohata K, Matsusaka K, Doi N, Mano Y, Takane K, Abe H, Yagi K, Matsuhashi N, Fukushima J, Fukayama M, Akagi K, Aburatani H, Nakajima A, Kaneda A.
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Journal Title
Int J Cancer
Volume: 138
Issue: 7
Pages: 1634-44
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Evaluation of 18F-FDG uptake for detecting lymph node metastasis of gastric cancer: a prospective pilot study for one-to-one comparison of radiation dose and pathological findings.2015
Author(s)
Okumura Y, Aikou S, Onoyama H, Jinbo K, Yamagata Y, Mori K, Yamashita H, Nomura S, Takahashi M, Koyama K, Momose T, Abe H, Matsusaka K, Ushiku T, Fukayama M, Seto Y.
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Journal Title
World J Surg Oncol.
Volume: 13
Issue: 1
Pages: 327-327
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Loss of histone demethylase KDM6B enhances aggressiveness of pancreatic cancer through downregulation of C/EBPα.2014
Author(s)
Yamamoto K, Tateishi K, Kudo Y, Sato T, Yamamoto S, Miyabayashi K, Asaoka Y, Ijichi H, Hirata Y, Otsuka M, Nakai Y, Isayama H, Ikenoue T, Kurokawa M, Fukayama M, Kokudo N, Omata M and Koike K.
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Journal Title
Carcinogenesis
Volume: 35
Issue: 11
Pages: 2404-14
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Methylation epigenotypes and genetic features in colorectal laterally spreading tumors2014
Author(s)
Sakai E, Ohata K, Chiba H, Matsuhashi N, Doi N, Fukushima J, Endo H, Takahashi H, Tsuji S, Yagi K, Matsusaka K, Aburatani H, Nakajima A, Kaneda A.
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Journal Title
Int J Cancer
Volume: in press
Issue: 7
Pages: 1586-95
DOI
Related Report
Peer Reviewed / Open Access
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