| Project/Area Number |
26860258
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 組織幹細胞 / 幹細胞 / 細胞極性 / ヘミデスモソーム / COL17A1 / ITGA6 |
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| Outline of Final Research Achievements |
Cell polarity plays important functional roles in differentiation and proliferation of mammalian stem cells. However, the function and regulation of cell polarity in hair follicle stem cells (HFSCs) are unclear. COL17A1 is one of the hemidesmosomal transmembrane proteins that play a critical role in maintaining the linkage between the intracellular and the extracellular structural elements involved in epidermal integrity. Previously, we showed that COL17A1 is essential for maintenance of hair follicle stem cells (Cell Stem Cell 2011), that the maintenance of COL17A1 in HFSCs orchestrates the stem cell centric aging program of the epithelial mini-organ (Matsumura et al. Science 2016). In this study, we are investigating how COL17A1 and ITGA6 regulates the fate of hair follicle stem cells by focusing on cell polarity.
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