| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We analyze which intracellular signals are activated during the development and progression of gastric cancer. When cancer cells infiltrate and metastasize, its motility has been increased by the non-canonical Wnt signaling pathway. Here we have discovered that the intracellular scaffold protein Daple controls cell motility by the non-canonical Wnt signaling in gastric cancer cells. Daple depletion also suppressed liver metastasis in a mouse xenograft model of gastric cancer.
These results suggest that the non-canonical Wnt signaling pathway contributes to gastric cancer progression at least in part via Daple, which provides a new therapeutic opportunity for the treatment of the disease.
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