Regulation of Wnt signaling in the development of gastric cancer
| Project/Area Number |
26860261
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Nagoya University |
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Principal Investigator |
Takagishi Maki 名古屋大学, 医学系研究科, 研究機関研究員 (10723918)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Wntシグナル / 胃がん / Daple |
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| Outline of Final Research Achievements |
We analyze which intracellular signals are activated during the development and progression of gastric cancer. When cancer cells infiltrate and metastasize, its motility has been increased by the non-canonical Wnt signaling pathway. Here we have discovered that the intracellular scaffold protein Daple controls cell motility by the non-canonical Wnt signaling in gastric cancer cells. Daple depletion also suppressed liver metastasis in a mouse xenograft model of gastric cancer.
These results suggest that the non-canonical Wnt signaling pathway contributes to gastric cancer progression at least in part via Daple, which provides a new therapeutic opportunity for the treatment of the disease.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] TRIM27/MRTF-B-Dependent Integrin β1 Expression Defines Leading Cells in Cancer Cell Collectives.2014
Author(s)
Takuya Kato, Atsushi Enomoto, Takashi Watanabe, Hisashi Haga, Sumire Ishida, Yuji Kondo, Koichi Furukawa, Takeshi Urano, Shinji Mii, Liang Weng, Maki Ishida-Takagishi, Masato Asai, Naoya Asai, Kozo Kaibuchi, Yoshiki Murakumo, Masahide Takahashi.
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Journal Title
Cell reports.
Volume: 7
Issue: 4
Pages: 1156-1167
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Regulation of cargo-selective endocytosis by dynamin 2 GTPase-activating protein girdin.2014
Author(s)
Liang Weng, Atsushi Enomoto, Hiroshi Miyoshi, Kiyofumi Takahashi, Naoya Asai, Nobuhiro Morone, Ping Jiang, Jian An, Takuya Kato, Keisuke Kuroda, Takashi Watanabe, Masato Asai, Maki Ishida-Takagishi, Yoshiki Murakumo, Hideki Nakashima, Kozo Kaibuchi and Masahide Takahashi.
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Journal Title
EMBO Journal.
Volume: 33
Issue: 18
Pages: 2098-2112
DOI
Related Report
Peer Reviewed / Open Access
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