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Establishment of a novel therapeutic method for multiple sclerosis via plasmablasts

Research Project

Project/Area Number 26860262
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionOsaka University

Principal Investigator

Matsumoto Masanori  大阪大学, 免疫学フロンティア研究センター, 特任助教 (50542106)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords多発性硬化症 / IL-10 / plasmablast / plasmablasts / 脳脊髄炎
Outline of Final Research Achievements

B cells can suppress experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis, by secreting an anti-inflammatory cytokine, IL-10. However, whether human plasmablasts can also serve as predominant IL-10 producers remains unknown. By culturing peripheral blood B cells derived from healthy donors in vitro, we found that plasmablasts predominantly produced IL-10 and that their IL-10 production was mediated by activation of IRF4 and NFAT. Thus, these results suggest that human plasmablasts can serve as IL-10 producers to suppress multiple sclerosis.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2015 2014

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Book (1 results)

  • [Journal Article] Signals controlling the development and activity of regulatory B-lineage cells.2015

    • Author(s)
      Baba, Y., Matsumoto, M., Kurosaki, T.
    • Journal Title

      Int Immunol.

      Volume: 27 Issue: 10 Pages: 487-93

    • DOI

      10.1093/intimm/dxv027

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation.2014

    • Author(s)
      Mastumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nut, S. L., Sakaguchi, S., Takeda, K., Kurosaki, T., and Baba, Y.
    • Journal Title

      Immunity

      Volume: 41 Issue: 6 Pages: 1040-1051

    • DOI

      10.1016/j.immuni.2014.10.016

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Book] 臨床免疫・アレルギー科2015

    • Author(s)
      松本真典
    • Total Pages
      7
    • Publisher
      科学評論社
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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