Establishment of a novel therapeutic method for multiple sclerosis via plasmablasts
| Project/Area Number |
26860262
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Osaka University |
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Principal Investigator |
Matsumoto Masanori 大阪大学, 免疫学フロンティア研究センター, 特任助教 (50542106)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 多発性硬化症 / IL-10 / plasmablast / plasmablasts / 脳脊髄炎 |
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| Outline of Final Research Achievements |
B cells can suppress experimental autoimmune encephalomyelitis, a mouse model of multiple sclerosis, by secreting an anti-inflammatory cytokine, IL-10. However, whether human plasmablasts can also serve as predominant IL-10 producers remains unknown. By culturing peripheral blood B cells derived from healthy donors in vitro, we found that plasmablasts predominantly produced IL-10 and that their IL-10 production was mediated by activation of IRF4 and NFAT. Thus, these results suggest that human plasmablasts can serve as IL-10 producers to suppress multiple sclerosis.
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Report
(3 results)
Research Products
(3 results)
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[Journal Article] Interleukin-10-producing plasmablasts exert regulatory function in autoimmune inflammation.2014
Author(s)
Mastumoto, M., Baba, A., Yokota, T., Nishikawa, H., Ohkawa, Y., Kayama, H., Kallies, A., Nut, S. L., Sakaguchi, S., Takeda, K., Kurosaki, T., and Baba, Y.
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Journal Title
Immunity
Volume: 41
Issue: 6
Pages: 1040-1051
DOI
Related Report
Peer Reviewed / Open Access
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