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Investigation of the autoimmune diseases pathogenesis through microRNA exhaustive analysis

Research Project

Project/Area Number 26860265
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionJuntendo University

Principal Investigator

Hayakawa Kunihiro  順天堂大学, 医学(系)研究科(研究院), 博士研究員 (00573007)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsmiRNA / 関節リウマチ / 全身性エリテマトーデス / 炎症 / 自己免疫疾患 / 炎症応答 / SLE
Outline of Final Research Achievements

Rheumatoid arthritis (RA) and systemic lupus erythematosus are typical autoimmune disease. In this study, we revealed the microRNA (miRNA) is associated with these disease activities. In the study targeting of RA, we first performed miRNA array analysis of plasma from patient with before and after treatment of abatacept, and identified the fluctuated miRNA between before and after treatment. Next, we intended to investigate the influence of these miRNAs in RA disease activity, and tested to confirm inflammatory responses using RA synoviocyte. Interestingly, up-regulated miRNAs by treatment have anti-inflammatory effect. Conversely, down-regulated miRNAs showed effect to increase inflammation. That is, plasma miRNA from high activity RA patients may contribute the sustention of disease activity, and plasma miRNA in low activity RA patients may conversely assist the suppression of inflammation.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (11 results)

All 2017 2016 2015 2014

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (8 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] The effectiveness of new triple combination therapy using synthetic disease-modifying anti-rheumatic drugs with different pharmacological function against rheumatoid arthritis: the verification by an in vitro and clinical study.2017

    • Author(s)
      Hirai T, Ikeda K, Fujishiro M, Tsushima H, Hayakawa K, Suzuki S, Yamaguchi A, Nozawa K, Morimoto S, Takasaki Y, Ogawa H, Takamori K, Tamura N, Sekigawa I
    • Journal Title

      Clin Rheumatol

      Volume: 36 Issue: 1 Pages: 51-58

    • DOI

      10.1007/s10067-016-3458-8

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Inhibition of each module of connective tissue growth factor as a potential therapeutic target for rheumatoid arthritis.2015

    • Author(s)
      Miyashita T, Morimoto S, Fujishiro M, Hayakawa K, Suzuki S, Ikeda K, Miyazawa K, Morioka M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y.
    • Journal Title

      Autoimmunity

      Volume: 49(2) Issue: 2 Pages: 109-14

    • DOI

      10.3109/08916934.2015.1113405

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of the insulin-like growth factor system is a potential therapy for rheumatoid arthritis.2014

    • Author(s)
      Suzuki S, Morimoto S, Fujishiro M, Kawasaki M, Hayakawa K, Miyashita T, Ikeda K, Miyazawa K, Yanagida M, Takamori K, Ogawa H, Sekigawa I, Takasaki Y
    • Journal Title

      Autoimmunity

      Volume: - Issue: 4 Pages: 251-8

    • DOI

      10.3109/08916934.2014.976631

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] The investigation of the Connective Tissue Growth Factor in the pathogenesis of imiquimod-induced psoriasis-like dermatitis mice.2016

    • Author(s)
      Hayakawa K, Fujishiro M, Yoshida Y, Tsushima H, Hirai T, Ikeda K, Morimoto M, Sekigawa I
    • Organizer
      第45回日本免疫学会学術集会
    • Place of Presentation
      沖縄県宜野湾市
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] 関節リウマチ炎症局所の脂質メディエーターの測定方法の確立とその役割の検討2016

    • Author(s)
      早川国宏、藤城真樹、芳田祐子、宮下知子、津島浩、平井琢也、池田圭吾、森本真司、関川巖
    • Organizer
      第60回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] SLEモデルマウスおよびJAK阻害薬を用いたインターフェロンと転写制御因子の調節に関わる検討2016

    • Author(s)
      池田圭吾、早川国宏、藤城真樹、川崎美紀子、平井琢也、津島浩、森本真司、髙﨑芳成、関川巖
    • Organizer
      第60回日本リウマチ学会総会・学術集会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-04-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] The implication of the Connective Tissue Growth Factor (CTGF) in the pathogenesis of psoriasis.2015

    • Author(s)
      Hayakawa K, Fujishiro M, Masuzawa M, Yoshida Y, Miyashita T, Ikeda K, Morimoto S, Sekigawa I
    • Organizer
      第44回日本免疫学会学術集会
    • Place of Presentation
      札幌コンベンションセンター (北海道・札幌市)
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Pan JAK Inhibitor Tofacitinib Ameliorate Autoimmunity and Nephritis in Lupus Prone Mice Via Inhibition of Interferon Signaling Pathway.2015

    • Author(s)
      Ikeda K, Hayakawa K, Fujishiro M, Kawasaki M, Hiari T, Morimoto S, Takasaki Y, Sekigawa I
    • Organizer
      2015 American College of Rheumatorogy Annual Meeting
    • Place of Presentation
      San Francisco (アメリカ)
    • Year and Date
      2015-11-06
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 関節リウマチ発症におけるCTGF各moduleの関与について2015

    • Author(s)
      宮下知子、森本真司、藤城真樹、早川国宏、池田圭吾、関川巖、高崎芳成
    • Organizer
      第59回日本リウマチ学会総会・学術集会
    • Place of Presentation
      名古屋国際会議場 (愛知県・名古屋市)
    • Year and Date
      2015-04-23
    • Related Report
      2015 Research-status Report
  • [Presentation] インスリン用成長因子系阻害による新規関節リウマチ治療の可能性の検討2014

    • Author(s)
      鈴木智、森本真司、藤城真樹、宮下知子、川崎美紀子、早川国宏、池田圭吾、関川巖、高崎芳成
    • Organizer
      日本リウマチ学会総会・学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] JAK阻害剤tofacitinibはCD4陽性T細胞のIFNシグナルに加えCD28シグナルの抑制を介して全身性エリテマトーデスの活動性を抑制しうる2014

    • Author(s)
      池田圭吾、藤城真樹、早川国宏、川崎美紀子、森本真司、高崎芳成、関川巖
    • Organizer
      日本リウマチ学会総会・学術集会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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