Revealing the transcriptional network of the oncogenicity of intestinal stem cells and the development of new colorectal cancer therapy

• Project/Area Number: 26860266
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Jichi Medical University (2015); Kyorin University (2014)
• Principal Investigator: Nakaya Takeo 自治医科大学, 医学部, 講師 (80512277)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 大腸癌 / KLF5 / 腸上皮幹細胞 / 蛋白間相互作用 / 癌選択的抑制治療 / KLF / 腸上皮 / 組織幹細胞

Outline of Final Research Achievements

We discovered that transcriptional factor KLF5 is essential for the oncogenicity of intestinal stem cells. We speculated that selective suppression of the pathogenic function of KLF5 may enable the selective suppression of colorectal cancers without damaging normal cells. We have already obtained the preliminary favorable results. We will promote the research and development.