Relationship between anaerobic metabolisms and organelle evolution of Entamoeba histolytica
| Project/Area Number |
26860275
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | Japan Agency for Marine-Earth Science and Technology (2016)
University of Tsukuba (2014-2015) |
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Principal Investigator |
CHIBA Yoko 国立研究開発法人海洋研究開発機構, 深海・地殻内生物圏研究分野, ポストドクトラル研究員 (70638981)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | オルガネラ / 進化 / 寄生虫 / オルガネラ進化 / ミトコンドリア / エネルギー代謝 / 代謝生化学 |
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| Outline of Final Research Achievements |
Mitochondria, which function as the powerhouse of aerobic eukaryotic organisms, have undergone significant functional reduction and modifications under oxygen-reduced conditions, such as loss of oxygen-dependent ATP generation. Mitosomes are a highly degenerate form of mitochondria that lack the canonical functions of aerobic mitochondria. In the intestinal parasite Entamoeba, mitosomes exclusively contain enzymes for sulfate activation, which is not a typical function of mitochondria, and it remains a conundrum why Entamoeba has compartmentalized this pathway.
In this project, I proposed a hypothesis that a characteristic energy metabolism of Entamoeba was a key driving force for mitosome compartmentalization, and got data to support the hypothesis.
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Report
(4 results)
Research Products
(8 results)
