| Project/Area Number |
26860292
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Kagoshima University |
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Principal Investigator |
Iizasa Ei'ichi 鹿児島大学, 医歯学域医学系, 助教 (20631998)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 結核 / ITAM / 自然免疫 / 受容体 / 結核菌 / マクロファージ / 自然免疫受容体 / 感染防御 |
|---|
| Outline of Final Research Achievements |
For the identification of novel myeloid ITAM-coupled receptors (mITAMRs) that recognize Mycobacterium tuberculosis (M. tuberculosis), we have screened ITAMR library. As the result, we identified two novel ITAMRs, IgSFR2 and IgSFR5. In addition, We have identifed the ligands of the receptors. MA-containing lipids are the ligands for IgSFR2 and cardiolipin is that for IgSFR5. Furthermore, we have analyzed the function of IgSFR2 and found that IgSFR2 recognizes the ligands and plays important roles in the regulation of immune response against M. tuberculosis for the eradication of the infection.
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