Signals of epithelial cells facilitate to translocation of Pseudomonas aeruginosa through the epithelial tissues
| Project/Area Number |
26860295
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bacteriology (including mycology)
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| Research Institution | Kyoto Pharmaceutical University |
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Principal Investigator |
Hayashi Naoki 京都薬科大学, 薬学部, 助教 (70707463)
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| Research Collaborator |
GOTOH Naomasa 京都薬科大学, 薬学部, 教授 (30121560)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 感染症 / 細菌 / 緑膿菌 / 上皮細胞 / トランスロケーション / 鞭毛 / ムチン / 化学走化性 / べん毛 / 敗血症 / 腸管 / 感知 |
|---|
| Outline of Final Research Achievements |
The prevention and treatment of opportunistic infections with immunocompromised host are required in the developed countries including Japan. The colonization of Pseudomonas aeruginosa in respiratory, urinary, and gastrointestinal tracts in immunocompromised patients can trigger a wide range of severe acute and chronic infectious diseases. In particular, translocation of the colonized P. aeruginosa through epithelial tissues, which are covered with mucin, can cause severe bacteremia leading to fatal sepsis. Here, we found that P. aeruginosa, which was induced the acceleration of flagellar motility by the smaller protein secreted from epithelial cells, can penetrate the mucin layer. Further studies will be required to clarify the translocation mechanisms in P. aeruginosa, our studies could lead to new therapeutic strategies for P. aeruginosa gut-derived sepsis.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] The pilT gene contributes to type III ExoS effector injection into epithelial cells in Pseudomonas aeruginosa.2016
Author(s)
Shikata, M., Hayashi, N., Fujimoto, A., Nakamura, T., Matsui, N., Ishiyama, A., Maekawa, Y., Gotoh, N.
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Journal Title
J. Infect. Chemother.
Volume: 22
Issue: 4
Pages: 216-220
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Pseudomonas aeruginosa injects type III effector ExoS into epithelial cells through the function of type IV pili.2015
Author(s)
Hayashi, N., Nishizawa, H., Kitao, S., Deguchi, S., Nakamura, T., Fujimoto, A., Shikata, M., and Gotoh, N.
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Journal Title
FEBS lett.
Volume: 589
Issue: 8
Pages: 890-896
DOI
Related Report
Peer Reviewed
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[Presentation] Pseudomonas aeruginosa PAO1 Strain Injects Type III Effector ExoS into Cultured Epithelial Cells Using Type IV Pili.2015
Author(s)
Hayashi, N., Nishizawa, H., Kitao, S., Deguchi, S., Nakamura, T., Fujimoto, A., and Gotoh, N.
Organizer
American society for microbiology 115th general meeting.
Place of Presentation
New Orleans
Year and Date
2015-05-30
Related Report
Int'l Joint Research
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