Development of therapeutic measures against hantavirus infection using animal model
| Project/Area Number |
26860298
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Hokkaido University |
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Principal Investigator |
Shimizu Kenta 北海道大学, 医学研究科, 助教 (20466840)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | CD8陽性T細胞 / ハンタウイルス / 動物モデル / 病態 / 治療 / CD8 / T細胞 / CXCL9 / 血管内皮増殖因子 |
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| Outline of Final Research Achievements |
Although host immunity is thought to be involved in the pathogenesis of hantavirus infection, the mechanism remains to be elucidated. In this study, I tried to identify immune cells relating to the disease development of hantavirus infection using a mouse model and a technique to deplete specific immune cells by antibody administration. As a result, I found that CD8+ T cells that have an important role in cell-mediated immunity were involved in the disease development of hantavirus infection. I anticipate that CD8+ T cells will be a possible target for the therapeutic measures for hantavirus infection.
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Report
(4 results)
Research Products
(3 results)
