Research Project
Grant-in-Aid for Young Scientists (B)
YB-1 accumulates in the centrosome with influenza virus genome and formed a toroidal structure with a beads-on-a-string distribution around centriole. We also found that YB-1 localized at the centrosome in uninfected cells during mitotic phase and stimulates microtubule nucleation from the centrosome. Thus, it is likely that influenza virus recruits YB-1 at the centrosome to stimulate microtubule assembly. It is also revealed that, in infected cells, recycling endosomes accumulate in pericentrosomal organelle, called endocytic recycling compartments (ERC), through the centrosome maturation by recruiting YB-1. Further, we found that cholesterol accumulates in ERC with the virus genome and the cholesterol-enriched ERC is important for clustering of viral membrane proteins at the plasma membrane. These results suggest that cholesterol could be a trigger for budozone formation concomitantly with the virus genome trafficking to the plasma membrane (PLoS Pathog., 2015).
All 2016 2015 2014 Other
All Journal Article (7 results) (of which Int'l Joint Research: 1 results, Peer Reviewed: 7 results, Open Access: 5 results, Acknowledgement Compliant: 5 results) Presentation (9 results) (of which Int'l Joint Research: 3 results, Invited: 2 results) Remarks (1 results)
J. Virol.
Volume: 90 Issue: 8 Pages: 4105-4114
10.1128/jvi.00120-16
PLoS pathogens
Volume: 11 Issue: 11 Pages: e1005284-e1005284
10.1371/journal.ppat.1005284
120007129744
eLife
Volume: 4
10.7554/elife.08939
120007135522
Scientific Reports
Volume: 5 Issue: 1 Pages: 8768-8768
10.1038/srep08768
120007130347
Volume: 5 Issue: 1 Pages: 9163-9163
10.1038/srep09163
120007130320
Virology
Volume: 476 Pages: 141-150
10.1016/j.virol.2014.12.016
Molecular cell
Volume: 53 Issue: 3 Pages: 393-406
10.1016/j.molcel.2014.01.009
http://www.md.tsukuba.ac.jp/basic-med/infectionbiology/virology/