Generation of polyreactive B cells in murine herpesvirus infection
| Project/Area Number |
26860303
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 自己抗体産生 / 自己反応性B細胞 / 持続性ウイルス感染 / 液性免疫応答 / 獲得免疫 / 多分子反応性抗体 |
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| Outline of Final Research Achievements |
To examine immunological mechanisms in autoantibody production in viral infection, we have utilized murine gamma-herpesvirus 68 (MHV68) infection to inbred mice. In this study, we found that MHV68 infection induced polyreactive B cell clones in germinal center B cells and plasmablasts/plasma cells in mice infected with MHV68. It should be noted that a transient autoantibody appeared to be originated from short-lived plasmablasts in spleen. In long-lived plasma cells, an increased proportion of virus-mono-specific clones were observed, indicating a novel tolerance checkpoint in the plasmablast compartment.
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Report
(3 results)
Research Products
(3 results)
