| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
To examine immunological mechanisms in autoantibody production in viral infection, we have utilized murine gamma-herpesvirus 68 (MHV68) infection to inbred mice. In this study, we found that MHV68 infection induced polyreactive B cell clones in germinal center B cells and plasmablasts/plasma cells in mice infected with MHV68. It should be noted that a transient autoantibody appeared to be originated from short-lived plasmablasts in spleen. In long-lived plasma cells, an increased proportion of virus-mono-specific clones were observed, indicating a novel tolerance checkpoint in the plasmablast compartment.
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