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Design of vaccine antigen focused on the epitopes recognized by broad neutralizing antibodies

Research Project

Project/Area Number 26860304
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Virology
Research Institution一般財団法人阪大微生物病研究会

Principal Investigator

Inoue Yuji  一般財団法人阪大微生物病研究会, 研究部 探索研究課, 主任 (90548869)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsワクチン / インフルエンザ / エピトープ / ウイルス
Outline of Final Research Achievements

In this study, we attempted to construct a vaccine complex to protect infection from a broad range of influenza viral strains. Here we focused on the "stem region" in the hemagglutinin protein on the surface of influenza virion. The stem region is known to be less-variable but less-accessible compared to another part called "head region". To increase accessibility of the stem region, we prepared recombinant HA proteins and tried to bind them onto the surface of nanoparticles through the head region, on which HA molecules are inverted to expose the stem region.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Human monoclonal antibodies derived from a patient infected with 2009 pandemic influenza A virus broadly cross-neutralize group 1 influenza viruses2014

    • Author(s)
      Pan Y, Sasaki T, Kubota-Koketsu R, Inoue Y, Yasugi M, Yamashita A, Ramadhany R, Arai Y, Du A, Boonsathorn N, Ibrahim MS, Daidoji T, Nakaya T, Ono K, Okuno Y, Ikuta K, Watanabe Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 450 Issue: 1 Pages: 42-48

    • DOI

      10.1016/j.bbrc.2014.05.060

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] インフルエンザワクチンの有効性評価法としてのフォーカスウイルス中和試験法の検討2015

    • Author(s)
      井上雄嗣
    • Organizer
      第19回日本ワクチン学会学術集会
    • Place of Presentation
      名鉄犬山ホテル
    • Year and Date
      2015-11-14
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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