Design of vaccine antigen focused on the epitopes recognized by broad neutralizing antibodies
| Project/Area Number |
26860304
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
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| Research Institution | 一般財団法人阪大微生物病研究会 |
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Principal Investigator |
Inoue Yuji 一般財団法人阪大微生物病研究会, 研究部 探索研究課, 主任 (90548869)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ワクチン / インフルエンザ / エピトープ / ウイルス |
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| Outline of Final Research Achievements |
In this study, we attempted to construct a vaccine complex to protect infection from a broad range of influenza viral strains. Here we focused on the "stem region" in the hemagglutinin protein on the surface of influenza virion. The stem region is known to be less-variable but less-accessible compared to another part called "head region". To increase accessibility of the stem region, we prepared recombinant HA proteins and tried to bind them onto the surface of nanoparticles through the head region, on which HA molecules are inverted to expose the stem region.
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Report
(3 results)
Research Products
(2 results)
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[Journal Article] Human monoclonal antibodies derived from a patient infected with 2009 pandemic influenza A virus broadly cross-neutralize group 1 influenza viruses2014
Author(s)
Pan Y, Sasaki T, Kubota-Koketsu R, Inoue Y, Yasugi M, Yamashita A, Ramadhany R, Arai Y, Du A, Boonsathorn N, Ibrahim MS, Daidoji T, Nakaya T, Ono K, Okuno Y, Ikuta K, Watanabe Y
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Journal Title
Biochem Biophys Res Commun
Volume: 450
Issue: 1
Pages: 42-48
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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