Cancer immunosurveillance mediated by innate immune receptors
Project/Area Number |
26860316
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | The University of Tokyo |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 抗腫瘍免疫 / 自然免疫 |
Outline of Final Research Achievements |
The critical role of innate immune receptors in mediating innate and adaptive immune responses against invading pathogens is well known. However, it has been enigmatic if and how these receptors contribute to anti-tumor responses. In this study, we demonstrated that the dendritic cells and macrophages produce an innate immune receptor called Dectin-1 which recognizes a molecule found on the surface of some, but not all, types of tumor cell. In doing so, Dectin-1 activates a critical signaling pathway and directs the activity of the natural killer cells so that they can effectively kill tumor cells.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Recognition of tumor cells by Dectin-1 orchestrates innate immune cells for anti-tumor responses.2014
Author(s)
Chiba S, Ikushima H, Ueki H, Yanai H, Kimura Y, Hangai S, Nishio J, Negishi H, Tamura T, Saijo S, Iwakura Y, Taniguchi T.
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Journal Title
eLife
Volume: 04177
Pages: 04177-04177
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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