| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Outline of Final Research Achievements |
Chemokines and chemokine receptors play important roles in the recruitment of leukocytes to inflammation sites in inflammatory diseases including rheumatoid arthritis. In this study, we investigated the role of FROUNT, an up-regulator of chemokine signaling, in the onset and progression of rheumatoid arthritis. FROUNT deficient mice exhibited decreases in the rate of onset and severity of collagen-induced arthritis. Our data suggest that FROUNT is involved in both immune response to collagen and inflammatory phase in the disease course of arthritis. FROUNT-deficient mice exhibited decreases in a subset of macrophages and Th17 subset and increases in Treg subset in CD4 T cell population. Thus, a chemokine signal up-regulator FROUNT has turned out to be a promising target for rheumatoid arthritis to lessen arthritis-related immune response and inflammation.
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