Molecular regulation of chronic inflammatory disease by a novel chemokine-receptor associating protein FROUNT
| Project/Area Number |
26860317
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TODA Etsuko 東京大学, 大学院医学系研究科(医学部), 特任助教 (00589327)
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| Research Collaborator |
TERASHIMA Yuya
NANKI Toshihiro
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | ケモカイン / ケモカイン受容体 / 慢性炎症性疾患 / 関節リウマチ / FROUNT / フロント / コラーゲン誘発性関節炎 |
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| Outline of Final Research Achievements |
Chemokines and chemokine receptors play important roles in the recruitment of leukocytes to inflammation sites in inflammatory diseases including rheumatoid arthritis. In this study, we investigated the role of FROUNT, an up-regulator of chemokine signaling, in the onset and progression of rheumatoid arthritis. FROUNT deficient mice exhibited decreases in the rate of onset and severity of collagen-induced arthritis. Our data suggest that FROUNT is involved in both immune response to collagen and inflammatory phase in the disease course of arthritis. FROUNT-deficient mice exhibited decreases in a subset of macrophages and Th17 subset and increases in Treg subset in CD4 T cell population. Thus, a chemokine signal up-regulator FROUNT has turned out to be a promising target for rheumatoid arthritis to lessen arthritis-related immune response and inflammation.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Robust Antitumor Effects of Combined Anti-CD4-Depleting Antibody and Anti-PD-1/PD-L1 Immune Checkpoint Antibody Treatment in Mice.2015
Author(s)
Ueha S, Yokochi S, Ishiwata Y, Ogiwara H, Chand K, Nakajima T, Hachiga K,Shichino S, Terashima Y, Toda E, Shand FH, Kakimi K, Ito S, Matshushima K.
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Journal Title
Cancer Immunol Res.
Volume: Epub ahead of print
Pages: 631-640
DOI
Related Report
Peer Reviewed
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[Journal Article] Robust anti-tumor effects of combined anti-CD4 depleting antibody and anti-PD-1/PD-L1 immune checkpoint antibody treatment in mice.2015
Author(s)
Ueha S, Yokochi S, Ishiwata Y, Ogiwara H, Chand K, Nakajima T, Hachiga K, Shichino S, Terashima Y, Toda E, Shand FH, Kakimi K, Ito S, Matshushima K.
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Journal Title
Cancer Immunol Res.
Volume: 印刷中
Related Report
Peer Reviewed
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[Journal Article] Structural basis for the binding of the membrane-proximal C-terminal region of chemokine receptor CCR2 with the cytosolic regulator FROUNT.2015
Author(s)
Esaki K, Yoshinaga S, Tsuji T, Toda E, Terashima Y, Saitoh T, Kohda D, Kohno T, Osawa M, Ueda T, Shimada I, Matsushima K, Terasawa H
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Journal Title
FEBS J.
Volume: 281
Pages: 5552-5566
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Identification of a binding element for the cytoplasmic regulator FROUNT in the membrane-proximal C-terminal region of chemokine receptors CCR2 and CCR52014
Author(s)
Toda E, Terashlma Y, Esakii K, Yoshinaga S, Sugihara M, Kofuku Y, Shimada I, Suwa M, Kanegasaki S, Terasawa H, Matsushima K.
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Journal Title
Biochem J.
Volume: Vol.457
Pages: 313-22
DOI
Related Report
Peer Reviewed
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