Project/Area Number |
26860321
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Immunology
|
Research Institution | Nagoya University |
Principal Investigator |
Ohmi Yuhsuke 名古屋大学, 医学(系)研究科(研究院), 特任助教 (10584758)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 関節リウマチ / 自己抗体 / シアル酸 / N型糖鎖 / CIA / IgG / ST6Gal1 / ACPA |
Outline of Final Research Achievements |
Although IgG molecule has single N-glycosylation site in the Fc region and various glycosylation patterns have been reported, their functions have been unclear. Then, we have established ST6Gal1-deficient mice lines lacking sialic acids specifically in activated B cells, and have tried to induce experimental arthritis in them. Consequently, it has been demonstrated that sialylation-deficient mice exhibit exacerbation of RA features compared to wild type mice. On the other hand, administration of sialylated auto-antibody IgG into RA-model mice resulted in rather suppression of clinical features of RA.
|