Role of sialylated IgG and novel therapeutic strategy in rheumatoid arthritis
Project/Area Number |
26860321
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | Nagoya University |
Principal Investigator |
Ohmi Yuhsuke 名古屋大学, 医学(系)研究科(研究院), 特任助教 (10584758)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 関節リウマチ / 自己抗体 / シアル酸 / N型糖鎖 / CIA / IgG / ST6Gal1 / ACPA |
Outline of Final Research Achievements |
Although IgG molecule has single N-glycosylation site in the Fc region and various glycosylation patterns have been reported, their functions have been unclear. Then, we have established ST6Gal1-deficient mice lines lacking sialic acids specifically in activated B cells, and have tried to induce experimental arthritis in them. Consequently, it has been demonstrated that sialylation-deficient mice exhibit exacerbation of RA features compared to wild type mice. On the other hand, administration of sialylated auto-antibody IgG into RA-model mice resulted in rather suppression of clinical features of RA.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Sialylation converts arthritogenic IgG into inhibitors of collagen-induced arthritis.2016
Author(s)
Ohmi Y, Ise W, Harazono A, Takakura D, Fukuyama H, Baba Y, Narazaki M, Shoda H, Takahashi N, Ohkawa Y, Ji S, Sugiyama F, Fujio K, Kumanogoh A, Yamamoto K, Kawasaki N, Kurosaki T, Takahashi Y, Furukawa K.
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Journal Title
Nature Communications
Volume: in press
Issue: 1
Pages: 11205-11205
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor α and Yes Kinase.2015
Author(s)
Ohkawa Y, Momota H, Kato A, Hashimoto N, Tsuda Y, Kotani N, Honke K, Suzumura A, Furukawa K, Ohmi Y, Natsume A, Wakabayashi T, Furukawa K.
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Journal Title
J Biol Chem.
Volume: 290
Issue: 26
Pages: 16043-16058
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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