| Project/Area Number |
26860323
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Kyoto University |
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Principal Investigator |
Morita Daisuke 京都大学, ウイルス研究所, 助教 (40706173)
|
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | MHCクラス1 / リポペプチド / ミリスチン酸修飾 / HIV / 抗原提示 / MHCクラス１ / エイズ / ウイルス感染 |
|---|
| Outline of Final Research Achievements |
A new pathway for host defense has recently been discovered in the monkey AIDS model, in which lipopeptide-specific T cell responses develop to combat against infection. However, the molecular mechanisms underlying lipopeptide antigen (Ag) presentation remain elusive. In this study, we identified a lipopepide-Ag presenting rhesus MHC class I molecule, Mamu-B*098. A high-resolution X-ray crystallographic analysis of the Mamu-B*098:lipopeptide complex reveals the detailed binding manner (Morita et al. Nature Communications 2016, doi:10.1038/ncomms10356).
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