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Development of in vitro culture to generate disease-related-antigen-reactive cytotoxic T lymphocytes using iPSC technology

Research Project

Project/Area Number 26860324
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionKyoto University

Principal Investigator

Kawai Yohei  京都大学, iPS細胞研究所, 研究員 (90623364)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsiPS細胞 / CTL / iPSC / adaptive lymphoid cell / naive CTL / CD8alphabeta / Cytotoxic T cell / フィーダーフリー拡大培養
Outline of Final Research Achievements

Adoptive transfer of cytotoxic T lymphocytes (CTLs) is highly promising against cancer and chronic infection, however in conventional protocol of CTL preparation, cell exhaustion is inevitable and critically hampers production of sufficient number of CTLs. Thus we developed novel iPSC-technology-based system to regenerate CTLs in cost- and labor-effective manner and successfully produced CTLs, whose cytotoxic activity was equivalent to that of original cells.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2015 2014

All Presentation (4 results)

  • [Presentation] Generation of adaptive and innate-like lymphoid killer cells from a single T-iPSC2015

    • Author(s)
      河合 洋平
    • Organizer
      Kyoto T cell Conference
    • Place of Presentation
      京都
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of in vitro culture system to generate cytotoxic T cells using iPSC2014

    • Author(s)
      河合洋平
    • Organizer
      日本免疫学会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Development of in vitro culture system to generate cytotoxic T cells using iPSC technology2014

    • Author(s)
      河合洋平
    • Organizer
      日本血液学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-10-31 – 2014-11-02
    • Related Report
      2014 Research-status Report
  • [Presentation] iPS細胞技術を用いたがん抗原特異的細胞傷害性T細胞の大量調製法の開発2014

    • Author(s)
      河合洋平
    • Organizer
      日本がん免疫学会
    • Place of Presentation
      ひめぎんホール
    • Year and Date
      2014-07-30 – 2014-08-01
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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