| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
The molecular mechanisms of positive and negative selection of B cells in germinal center during the immune response have not been fully elucidated. It is important to understand these mechanisms because it has been thought that the dysregulation of the B cells selection in germinal center leads to autoimmune disease.
In this study, I revealed that CD3 molecule that is a major component of T cell antigen receptor complex expressed in germinal center B cells. In addition, these CD3-expressing B cells were highly sensitive apoptosis. Moreover, markedly increased levels of antigen-specific and auto-reactive antibodies were both detected when mice harboring CD3e-deficient B cells and normal T cells were immunized.
These results suggest that CD3e expressed in B cells plays critical roles in germinal center B cell selection during the immune response.
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