Analysis of the role of CD3 molecule expressing in germinal center B cells
Project/Area Number |
26860327
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Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | Kyoto University |
Principal Investigator |
Todo Kagefumi 京都大学, 医学研究科, 特定研究員 (50452561)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | B細胞 / 胚中心 / 免疫学 |
Outline of Final Research Achievements |
The molecular mechanisms of positive and negative selection of B cells in germinal center during the immune response have not been fully elucidated. It is important to understand these mechanisms because it has been thought that the dysregulation of the B cells selection in germinal center leads to autoimmune disease. In this study, I revealed that CD3 molecule that is a major component of T cell antigen receptor complex expressed in germinal center B cells. In addition, these CD3-expressing B cells were highly sensitive apoptosis. Moreover, markedly increased levels of antigen-specific and auto-reactive antibodies were both detected when mice harboring CD3e-deficient B cells and normal T cells were immunized. These results suggest that CD3e expressed in B cells plays critical roles in germinal center B cell selection during the immune response.
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Report
(4 results)
Research Products
(1 results)