Research Project
Grant-in-Aid for Young Scientists (B)
It has been reported that high expression of IL-6 is associated with the patients with rheumatoid arthritis. Recently, we found that AT-rich interactive domain containing 5a (Arid5a) stabilize IL-6 mRNA through binding to IL-6 3'UTR, which in turn elevates IL-6 level in vivo. In this study, we demonstrated that IL-6-induced Arid5a in T cells stabilized Stat3 mRNA by inhibiting the function of an RNAse Regnase-1, and thereby promoted the differentiation of Th17 cells. Thus, Arid5a contributes to elevation of IL-6 level in vivo, but also drives Th17 differentiation.
All 2016 2015
All Journal Article (1 results) (of which Peer Reviewed: 1 results, Open Access: 1 results) Presentation (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)
Journal of Experimental Medicine
Volume: 213 Issue: 4 Pages: 605-619
10.1084/jem.20151289