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Analysis of the mechanisms underlying maintaining of intestinal CX3CR1high macrophages homeostasis

Research Project

Project/Area Number 26860330
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionOsaka University

Principal Investigator

Kayama Hisako  大阪大学, 医学系研究科, 助教 (40548814)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords炎症性腸疾患 / 自然免疫 / 粘膜免疫 / 自然免疫細胞 / 腸管炎症 / 腸管恒常性維持機構の解明
Outline of Final Research Achievements

We identified that transcription factor Spi-C highly express in intestinal CX3CR1high macrophages. In addition, Spi-C inhibited expression of colitogenic pro-inflammatory cytokines IL-6 and IL-1a mRNA through the disruption of IRF5/NF-kB p65 heterodimer formation by directly interacting with IRF5 and thereby maintaining intestinal homeostasis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2016 2015

All Presentation (4 results) (of which Invited: 1 results)

  • [Presentation] CD163high CD160high cells regulate human intestinal homeostasis through suppression of CD4+ T cell proliferation.2016

    • Author(s)
      香山 尚子
    • Organizer
      日本免疫学会
    • Place of Presentation
      沖縄
    • Year and Date
      2016-12-05
    • Related Report
      2016 Annual Research Report
  • [Presentation] Dietary iron and transcription factor Spi-C regulate gut homeostasis through maintenance of CX3CR1high CD11b+ CD11c+ cells.2016

    • Author(s)
      香山 尚子
    • Organizer
      International Congress of Immunology
    • Place of Presentation
      メルボルン, オーストラリア
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Maintenance of intestinal Spi-C+ CX3CR1high regulatory myeloid cells by dietary iron.2015

    • Author(s)
      香山尚子
    • Organizer
      日本免疫学会
    • Place of Presentation
      北海道
    • Year and Date
      2015-11-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 食餌鉄依存的な腸管CX3CR1high細胞の維持機構 2015

    • Author(s)
      香山尚子
    • Organizer
      日本臨床免疫学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2019-12-27  

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