Analysis of the mechanisms underlying maintaining of intestinal CX3CR1high macrophages homeostasis
| Project/Area Number |
26860330
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Osaka University |
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Principal Investigator |
Kayama Hisako 大阪大学, 医学系研究科, 助教 (40548814)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 炎症性腸疾患 / 自然免疫 / 粘膜免疫 / 自然免疫細胞 / 腸管炎症 / 腸管恒常性維持機構の解明 |
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| Outline of Final Research Achievements |
We identified that transcription factor Spi-C highly express in intestinal CX3CR1high macrophages. In addition, Spi-C inhibited expression of colitogenic pro-inflammatory cytokines IL-6 and IL-1a mRNA through the disruption of IRF5/NF-kB p65 heterodimer formation by directly interacting with IRF5 and thereby maintaining intestinal homeostasis.
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Report
(4 results)
Research Products
(4 results)
