Analysis of the mechanisms underlying maintaining of intestinal CX3CR1high macrophages homeostasis

Research Project

Project/Area Number	26860330
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Immunology
Research Institution	Osaka University
Principal Investigator	Kayama Hisako 大阪大学, 医学系研究科, 助教 (40548814)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	炎症性腸疾患 / 自然免疫 / 粘膜免疫 / 自然免疫細胞 / 腸管炎症 / 腸管恒常性維持機構の解明
Outline of Final Research Achievements	We identified that transcription factor Spi-C highly express in intestinal CX3CR1high macrophages. In addition, Spi-C inhibited expression of colitogenic pro-inflammatory cytokines IL-6 and IL-1a mRNA through the disruption of IRF5/NF-kB p65 heterodimer formation by directly interacting with IRF5 and thereby maintaining intestinal homeostasis.

Report

(4 results)