Research Project
Grant-in-Aid for Young Scientists (B)
The aim of this research is to elucidate the molecular mechanism of the induction of autoimmunity as a disequilibrium of regulatory T cells and self-reactive T cells. For this aim, we have developed mice with varying structural alterations of ZAP-70 or quantitative changes in ZAP-70 expression levels to control T-cell receptor signaling levels. In these mice, we have analyzed the development of regulatory T cells and self-reactive T cells as well as their changes in TCR repertoires. We have also analyzed cellular functions of respective subsets in the periphery. Our analyses on these mice have suggested that there is a critical range of TCR signaling leading to spontaneous induction of autoimmunity.
All 2017 2016 2015 2014
All Journal Article (7 results) (of which Int'l Joint Research: 3 results, Peer Reviewed: 4 results, Open Access: 2 results, Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results, Invited: 1 results) Book (1 results)
Cell Research
Volume: 27 Issue: 1 Pages: 109-118
10.1038/cr.2016.151
腫瘍内科
Volume: 19 Pages: 41-46
Transplant Direct
Volume: 2 Issue: 12 Pages: e118-e118
10.1097/txd.0000000000000630
Science
Volume: 348(6234) Issue: 6234 Pages: 506-507
10.1126/science.aab2998
がん分子標的治療
Volume: 13(4) Pages: 66-70
Cell Death and Disease
Volume: 6 Issue: 1 Pages: e1590-e1590
10.1038/cddis.2014.561
Volume: 346 Issue: 6207 Pages: 363-8
10.1126/science.1259077