| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
We focused on the role of CD2 in regulatory T (Treg) cells. We examined whether the CD2 signaling solely affects the function and induction of Treg cells. CD48-Fc, which is composed of extra-cellular portion of murine CD48 and murine Fcγ, was used for CD2-stimulation. We found that CD2-stimuli up-regulated Foxp3 expression and maintained the regulatory functions in Treg cells. CD2-induced Foxp3 up-regulation was partially dependent on IL-2. It was found that CD2- and TCR-stimuli synergistically increased the Foxp3 expression in Treg cells. But, CD2-stimuli decrease Bim expression as compared with TCR-stimuli, supporting survival Treg cells. Furthermore, we found that CD2-stimuli induced Foxp3 expression in naive T cells in the presence of TGF-β. It was confirmed that PI3K/AKT and JAK/STAT signals were involved in CD2-induced Foxp3 expression in naive T cells. Importantly, the CD2-induced Treg cells exerted regulatory effects on CD8+ T cell activation.
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