Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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Outline of Final Research Achievements |
Dcir2-/- CD4+ cDCs showed a higher secretion of proinflammatory cytokines and an enhanced T-cell priming after stimulation with TLR ligands than wild-type (WT) CD4+ cDCs. Furthermore, Dcir2-/- mice exhibit a hyperinflammatory response associated with the excessive production of cytokines. On antigenic immunization, Dcir2-/- mice showed a more enhanced autoimmune pathogenesis than WT mice. Thus, our findings suggest that DCIR2 provides an inhibitory signal for the fine-tuning of the function of CD4+ cDCs to maintain immune homeostasis and prevent autoimmune diseases.
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