| Project/Area Number |
26860340
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Research Collaborator |
YOSHIMOTO TOMOHIRO 兵庫医科大学, 医学部, 教授 (60241171)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | IgE / Th2 / 気道 / アレルギー / IL-33 / TSLP / エンドトキシン |
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| Outline of Final Research Achievements |
We investigated the mechanisms underlying IgE responses induced by particulate allergen exposure in lungs. We showed that B-cell-intrinsic MyD88 signaling activated by endogenous ligands, IL-1α, IL-1β, and IL-18, played a critical role in the antigen-specific IgE responses in lungs exposed to pollen allergens.
In addition, we investigated a novel role of Th2 cells in allergic airway diseases. Using an OVA-specific Th2 cells adoptive transfer model, we found that nasal CD4+ T cell activation followed by endotoxin exposure elicited IgE-independent rhinitis symptoms. This study shows the presence of T-cell-dependent and non-IgE-mediated nasal hypersensitivity-like reaction in mice.
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