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Development of a novel bone-targeting anti-osteoporotic agent

Research Project

Project/Area Number 26860359
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Applied pharmacology
Research InstitutionHokuriku University

Principal Investigator

Takahashi Tatsuo  北陸大学, 薬学部, 准教授 (50445904)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
KeywordsEphrinB2 / 骨粗鬆症 / 骨芽細胞 / 破骨細胞 / 骨ターゲティング / 酸性オリゴペプチド / 卵巣切除マウス / ephrinB2
Outline of Final Research Achievements

Osteoporosis is associated with a decrease in bone mass, which is maintained by bone-forming osteoblasts and bone-resorbing osteoclasts. We demonstrated that ephrinB2 increased osteoblastic differentiation and decreased osteoclastic differentiation in vitro, and that intravenously injected ephrinB2 ameliorated the bone loss observed in osteoporotic mice. Moreover, we constructed bone-targeting ephrinB2, named as AcOP-ephrinB2, to maximize the therapeutic effect against osteoporosis. However, high dose of AcOP-ephrinB2 showed little anti-osteoporotic effect in osteoporotic mice, that is, long-term and large-amount of accumulation of AcOP-ephrinB2 in bone appeared to be disadvantage in the treatment for osteoporosis.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2018 2017

All Presentation (3 results)

  • [Presentation] 卵巣切除マウスの骨量減少に及ぼすEphrinB2の作用と酸性オリゴペプチド付加による影響2018

    • Author(s)
      阿部 史葉、山崎 京介、野村 政明、松尾 由理、高橋 達雄
    • Organizer
      日本薬学会第138年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酸性オリゴペプチド共役EphrinB2は卵巣切除マウスにおける骨量減少を抑制した2017

    • Author(s)
      山崎京介、高橋達雄、本山佳太、野村政明、古林伸二郎
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台
    • Year and Date
      2017-03-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 酸性オリゴペプチド共役EphrinB2は卵巣切除マウスにおける骨量減少を抑制した2017

    • Author(s)
      山崎 京介、高橋 達雄、本山 佳太、野村 政明、古林 伸二郎
    • Organizer
      日本薬学会第137年会
    • Related Report
      2017 Annual Research Report

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Published: 2014-04-04   Modified: 2019-03-29  

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