Genome-wide association analyses of copy number variations in sensitivity to addictive substances and vulnerability to dependence
Project/Area Number |
26860360
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Applied pharmacology
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Research Institution | Tokyo Metropolitan Institute of Medical Science |
Principal Investigator |
NISHIZAWA Daisuke 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (80450584)
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Research Collaborator |
IKEDA Kazutaka
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Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 薬物依存 / 薬物感受性 / 薬物感受性・依存症脆弱性個人差の遺伝要因 / コピー数多型・変異 / ゲノムワイド関連解析 |
Outline of Final Research Achievements |
Comprehensive analyses were conducted in subjects who underwent painful cosmetic orthognathic surgery involving opioid administration to investigate associations between copy number variations (CNVs) throughout the human genome and postoperative 24-h opioid requirements or preoperative analgesic effects of fentanyl as indices of opioid sensitivity. As a result, CNVs around the gene regions of the CHSY3 and HINT1 on chromosome 5 and the AGBL4, C1orf165, and ELAVL4 on chromosome 1 were identified as the best candidates for postoperative 24-h opioid requirements. In addition, CNVs around the gene regions of the FAM5B and SEC16B on chromosome 1 and the GBE1 and ADM2 on chromosome 3 were identified as the best candidates for preoperative analgesic effects of fentanyl.
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Report
(5 results)
Research Products
(85 results)
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[Journal Article] Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy.2018
Author(s)
2.Nishizawa D, Mieda T, Tsujita M, Nakagawa H, Yamaguchi S, Kasai S, Hasegawa J, Fukuda KI, Kitamura A, Hayashida M, Ikeda K.
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Journal Title
Pharmacogenomics
Volume: 19
Issue: 2
Pages: 113-127
DOI
Related Report
Peer Reviewed
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[Journal Article] Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nucleotide polymorphism and older age in Japanese2017
Author(s)
Tanabe Y, Shimizu C, Hamada A, Hashimoto K, Ikeda K, Nishizawa D, Hasegawa J, Shimomura A, Ozaki Y, Tamura N, Yamamoto H, Yunokawa M, Yonemori K, Takano T, Kawabata H, Tamura K, Fujiwara Y
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Journal Title
Cancer Chemother Pharmacol
Volume: 79(6)
Issue: 6
Pages: 1179-1186
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] ゲノムワイド関連解析 (GWAS) による腹腔鏡補助下大腸切除術後フェンタニル必要量に影響する遺伝子多型の同定2017
Author(s)
西澤大輔, 三枝勉, 辻田美紀, 天野功二郎, 田代浄, 石井利昌, 山口茂樹, 笠井慎也, 長谷川準子, 池田和隆, 北村晶, 林田眞和
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Journal Title
日本神経精神薬理学雑誌
Volume: 37(2)
Pages: 53-54
Related Report
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[Journal Article] KCNJ6 (GIRK2) 遺伝子rs2835859多型と術後鎮痛、疼痛感受性、及びニコチン依存との関連2016
Author(s)
西澤大輔, 福田謙一, 笠井慎也, 大谷保和, 長谷川準子, 佐藤直美, 山田英孝, 谷岡書彦, 椙村春彦, 林田眞和, 池田和隆
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Journal Title
日本神経精神薬理学雑誌
Volume: 36
Pages: 115-116
Related Report
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[Journal Article] Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy2016
Author(s)
Mieda T*, Nishizawa D*, Nakagawa H, Tsujita M, Imanishi H, Terao K, Yoshikawa H, Itoh K, Amano K, Tashiro J, Ishii T, Ariyama J, Yamaguchi S, Kasai S, Hasegawa J, Ikeda K, Kitamura A, Hayashida M (*: These authors contributed equally to this study.)
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Journal Title
Pharmacogenomics
Volume: 17
Pages: 133-145
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Association between AKT1 gene polymorphism rs2498794 and smoking-related traits with reference to cancer susceptibility2015
Author(s)
Nishizawa, D., Kasai, S., Hasegawa, J., Sato,N., Tanioka, F., Sugimura, H., Ikeda, K. and Dobashi, Y.
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Journal Title
Biomedical Research. International;
Volume: 2015.94.
Pages: 316829-316829
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements.2015
Author(s)
Aoki Y, Nishizawa D, Hasegawa J, Kasai S, Yoshida K, Koukita Y, Ichinohe T, Nagashima M, Katoh R, Satoh Y, Tagami M, Hayashida M, Fukuda K, Ikeda K.
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Journal Title
J Pharmacol Sci
Volume: 127
Issue: 3
Pages: 391-393
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] ゲノムワイド及び追加関連解析によるニコチン依存関連遺伝子多型の同定2015
Author(s)
西澤大輔, 笠井慎也, 長谷川準子, 佐藤直美, 谷岡書彦, 長島誠, 氏家寛, 橋本亮太, 田中雅嗣, 椙村春彦, 池田和隆
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Journal Title
日本神経精神薬理学雑誌
Volume: 35
Pages: 45-46
Related Report
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[Journal Article] Association Between <i>KCNJ6</i> (<i>GIRK2</i>) Gene Polymorphism rs2835859 and Post-operative Analgesia, Pain Sensitivity, and Nicotine Dependence2014
Author(s)
Nishizawa D, Fukuda K, Kasai S, Ogai Y, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Hayashida M, Ikeda K.
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Journal Title
Journal of Pharmacological Sciences
Volume: 126
Issue: 3
Pages: 253-263
DOI
NAID
ISSN
1347-8613, 1347-8648
Related Report
Peer Reviewed / Open Access
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[Presentation] ゲノムワイド関連解析(GWAS)による腹腔鏡補助下大腸切除術中レミフェンタニル投与速度に寄与する遺伝子多型の同定2018
Author(s)
西澤大輔, 三枝勉, 辻田美紀, 中川秀之, 山口茂樹, 笠井慎也, 長谷川準子, 福田謙一, 北村晶, 林田眞和, 池田和隆
Organizer
平成29年度新学術領域研究 学術研究支援基盤形成【先端モデル動物支援プラットフォーム】成果発表会
Related Report
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[Presentation] ゲノムワイド関連解析(GWAS)による慢性疼痛感受性遺伝子多型の同定2017
Author(s)
西澤大輔, 有田英子, 花岡一雄, 矢島直, 井関雅子, 加藤実, 小川節郎, 平沼彩子, 笠井慎也, 長谷川準子, 林田眞和, 池田和隆
Organizer
日本人類遺伝学会第62回大会
Related Report
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[Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil requirements during laparoscopic-assisted colectomy2017
Author(s)
Nishizawa D, Mieda T, Tsujita M, Nakagawa H, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K
Organizer
The American Society of Human Genetics 67th Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] Associations between polymorphisms close to the cAMP responsive element binding protein 1 (CREB1) gene and the activating transcription factor 2 (ATF2) gene and fentanyl sensitivity2017
Author(s)
Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
Organizer
5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
Related Report
Int'l Joint Research
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[Presentation] Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy2016
Author(s)
Nishizawa D, Mieda T, Nakagawa H, Tsujita M, Imanishi H, Terao K, Yoshikawa H, Itoh K, Amano K, Tashiro J, Ishii T, Ariyama J, Yamaguchi S, Kasai S, Hasegawa J, Ikeda K, Kitamura A, Hayashida M
Organizer
30th CINP World Congress of Neuropsychopharmacology
Place of Presentation
Seoul(Korea)
Year and Date
2016-07-05
Related Report
Int'l Joint Research
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[Presentation] Association between the rs7583431 single-nucleotide polymorphism close to the activating transcription factor 2 (ATF2) gene and the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test2016
Author(s)
Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
Organizer
30th CINP World Congress of Neuropsychopharmacology
Place of Presentation
Seoul(Korea)
Year and Date
2016-07-05
Related Report
Int'l Joint Research
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[Presentation] Activating transcription factor 2(ATF2)遺伝子近傍の遺伝子多型rs7583431と冷水誘発疼痛試験におけるフェンタニルの鎮痛効果との関連2016
Author(s)
青木謙典, 西澤大輔, 吉田香織, 長谷川準子, 笠井慎也, 髙橋香央里, 髙北義彦, 一戸達也, 林田眞和, 福田謙一, 池田和隆
Organizer
第46回日本神経精神薬理学会年会(JSNP)
Place of Presentation
Seoul(Korea)
Year and Date
2016-07-03
Related Report
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[Presentation] ゲノムワイド関連解析(GWAS)による腹腔鏡補助下大腸切除術後フェンタニル必要量に影響する遺伝子多型の同定2016
Author(s)
西澤大輔, 三枝勉, 中川秀之, 辻田美紀, 今西宏和, 寺尾和久, 吉川博昭, 伊藤一志, 天野功二郎, 田代浄, 石井利昌, 有山淳, 山口茂樹, 笠井慎也, 長谷川準子, 中山京子, 江畑裕子, 池田和隆, 北村晶, 林田眞和
Organizer
第46回日本神経精神薬理学会年会(JSNP)
Place of Presentation
Seoul(Korea)
Year and Date
2016-07-02
Related Report
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[Presentation] Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements2015
Author(s)
Aoki Y, Nishizawa D, Hasegawa J, Kasai S, Yoshida K, Koukita Y, Ichinohe T, Nagashima M, Katoh R, Satoh Y, Tagami M, Hayashida M, Fukuda K, Ikeda K
Organizer
4th Congress of Asian College of Neuropsychopharmacology
Place of Presentation
Taipei, Taiwan
Year and Date
2015-11-20
Related Report
Int'l Joint Research
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[Presentation] Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and postoperative analgesia, pain sensitivity, and nicotine dependence2015
Author(s)
Nishizawa D, Fukuda K, Kasai S, Ogai Y, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Hayashida M, Ikeda K
Organizer
4th Congress of Asian College of Neuropsychopharmacology
Place of Presentation
Taipei, Taiwan
Year and Date
2015-11-20
Related Report
Int'l Joint Research
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[Presentation] Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and postoperative analgesia, pain sensitivity, and nicotine dependence2015
Author(s)
Nishizawa D, Fukuda K, Kasai S, Ogai Y, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Hayashida M, Ikeda K
Organizer
The American Society of Human Genetics 65th Annual Meeting
Place of Presentation
Baltimore, USA
Year and Date
2015-10-08
Related Report
Int'l Joint Research
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[Presentation] ゲノムワイド関連解析によるオレキシン2受容体遺伝子多型Val308Ileとニコチン依存との関連の同定2014
Author(s)
西澤大輔, 笠井慎也, 佐藤直美, 谷岡書彦, 長島誠, 氏家寛, 橋本亮太, 田中雅嗣, 椙村春彦, 池田和隆
Organizer
平成26年度アルコール・薬物依存関連学会合同学術総会
Place of Presentation
パシフィコ横浜, 横浜
Year and Date
2014-10-03
Related Report
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[Presentation] PCLO SNP rs13438494 regulates DA and 5-HT uptake, accompanied with splicing efficiency and dependence-like behaviors in genomic association studies2014
Author(s)
Uno K, Nishizawa D, Seo S, Sasaki N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Ikeda K, Miyamoto Y, Nitta A
Organizer
29th CINP World Congress of Neuropsychopharmacology
Place of Presentation
Vancouver, Canada
Year and Date
2014-06-24
Related Report
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[Presentation] Associations of an orexin (hypocretin) receptor 2 gene polymorphism with nicotine dependence found in genome-wide and following association studies2014
Author(s)
Nishizawa D, Kasai S, Hasegawa J, Sato N, Tanioka F, Nagashima M, Ujike H, Hashimoto R, Tanaka M, Sugimura H, Ikeda K
Organizer
29th CINP World Congress of Neuropsychopharmacology
Place of Presentation
Vancouver, Canada
Year and Date
2014-06-23
Related Report
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[Presentation] Personalized pain control2014
Author(s)
Ikeda K, Nishizawa D, Hayashida M, Fukuda K
Organizer
2014 YONSEI BK21 PLUS-IGAKUKEN Joint Symposium
Place of Presentation
Soul, Korea
Year and Date
2014-06-20
Related Report
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