| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Comprehensive analyses were conducted in subjects who underwent painful cosmetic orthognathic surgery involving opioid administration to investigate associations between copy number variations (CNVs) throughout the human genome and postoperative 24-h opioid requirements or preoperative analgesic effects of fentanyl as indices of opioid sensitivity. As a result, CNVs around the gene regions of the CHSY3 and HINT1 on chromosome 5 and the AGBL4, C1orf165, and ELAVL4 on chromosome 1 were identified as the best candidates for postoperative 24-h opioid requirements. In addition, CNVs around the gene regions of the FAM5B and SEC16B on chromosome 1 and the GBE1 and ADM2 on chromosome 3 were identified as the best candidates for preoperative analgesic effects of fentanyl.
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