Genome-wide association analyses of copy number variations in sensitivity to addictive substances and vulnerability to dependence

• Project/Area Number: 26860360
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology
• Research Institution: Tokyo Metropolitan Institute of Medical Science
• Principal Investigator: NISHIZAWA Daisuke 公益財団法人東京都医学総合研究所, 精神行動医学研究分野, 主席研究員 (80450584)
• Research Collaborator: IKEDA Kazutaka
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 薬物依存 / 薬物感受性 / 薬物感受性・依存症脆弱性個人差の遺伝要因 / コピー数多型・変異 / ゲノムワイド関連解析

Outline of Final Research Achievements

Comprehensive analyses were conducted in subjects who underwent painful cosmetic orthognathic surgery involving opioid administration to investigate associations between copy number variations (CNVs) throughout the human genome and postoperative 24-h opioid requirements or preoperative analgesic effects of fentanyl as indices of opioid sensitivity. As a result, CNVs around the gene regions of the CHSY3 and HINT1 on chromosome 5 and the AGBL4, C1orf165, and ELAVL4 on chromosome 1 were identified as the best candidates for postoperative 24-h opioid requirements. In addition, CNVs around the gene regions of the FAM5B and SEC16B on chromosome 1 and the GBE1 and ADM2 on chromosome 3 were identified as the best candidates for preoperative analgesic effects of fentanyl.

Research Products

• [Journal Article] Genome-wide association study identifies polymorphisms associated with the analgcsic offoct of fentanyl in the prooporative cold pressor-induced pain test. (2018)
  • Author(s): Takahashi K, Nishizawa D, Kasai S, Koukita Y, Fukuda K, Ichinohe T, Ikcda K
  • Journal Title: J Pharmacol Sci Volume: 136 Issue: 3 Pages: 107-113
  • DOI: 10.1016/j.jphs.2018.02.002
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide scan identifies candidate loci related to romifentanil requiroments during laparoscopic-assisted colectomy. (2018)
  • Author(s): Nishizawa D, Mieda T, Tsujita M, Nakagawa H, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K
  • Journal Title: Pharmacogenomics Volume: 19 Issue: 2 Pages: 113-127
  • DOI: 10.2217/pgs-2017-0109
  • Peer Reviewed
• [Journal Article] Association between polymorphisms in the purinergic P2Y12 receptor gone and severity of both cancer pain and postoperative pain. (2018)
  • Author(s): Sumitani M, Nishizawa D, Nagashima M, Ikeda K, Abe H, Kato R, Ueda H, Yamada Y
  • Journal Title: Pain Med Volume: 19(2) Issue: 2 Pages: 348-354
  • DOI: 10.1093/pm/pnx102
  • Peer Reviewed
• [Journal Article] Association between N-methyl-D-aspartate receptor subunit 2B gene polymorphisms and alcohol dependence in a Japanese population (2017)
  • Author(s): Narita S, Yoshihara E, Nishizawa D, Kawai A, Ikeda K, Iwahashi K
  • Journal Title: Nihon Arukoru Yakubutsu Igakkai Zasshi Volume: 52(5) Pages: 156-167
  • NAID: 40021423809
  • Peer Reviewed
• [Journal Article] No association between the polymorphism rs6943555 in the AUTS2 gene and personality traits in Japanese university students. (2017)
  • Author(s): Narita S, Ikeda K, Nishizawa D, Yoshihara E, Numajiri M, Onozawa Y, Ohtani N, Iwahashi K
  • Journal Title: Psychiatry Investigation Volume: 14(5) Issue: 5 Pages: 681-686
  • DOI: 10.4306/pi.2017.14.5.681
  • Peer Reviewed / Open Access
• [Journal Article] Paclitaxel-induced sensory peripheral neuropathy is associated with an ABCB1 single nuclcotide polymorphism and older age in Japanese. (2017)
  • Author(s): Tanabe Y, Shimizu C, Hamada A, Hashimoto K, Ikeda K, Nishizawa D, Hasegawa J, Shimomura A, Ozaki Y, Tamura N, Yamamoto H, Yunokawa M, Yonemori K, Takano T, Kawabata H, Tamura K, Fujiwara Y
  • Journal Title: Cancer Chemother Pharmacol Volume: 79(6) Issue: 6 Pages: 1179-1186
  • DOI: 10.1007/s00280-017-3314-9
  • Peer Reviewed / Open Access
• [Journal Article] ゲノムワイド関連解析を利用したオピオイドのテーラーメイド医療への試み (2017)
  • Author(s): 三枝勉, 西澤大輔, 福田謙一, 池田和隆, 北村晶, 林田眞和
  • Journal Title: 麻酔・集中治療とテクノロジー2017 Volume: 2017 Pages: 16-21
• [Journal Article] 喫煙関連遺伝子多型の同定とその機能解析. 特定研究「ヒト発がんと遺伝子多型、喫煙との関連」 (2017)
  • Author(s): 池田和隆, 西澤大輔, 笠井慎也, 高松幸雄, 萩野洋子, 椙村春彦
  • Journal Title: 平成28年度喫煙科学研究財団研究年報 (リーダー: 椙村春彦) Volume: 2017 Pages: 655-660
• [Journal Article] Association between autism susceptibility candidate 2 haplotypes and alcohol dependence in a Japanese population (2017)
  • Author(s): Narita S, Iwahashi K, Yoshihara E, Kawai A, Nishizawa D, Ikeda K
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 37(3) Pages: 97-98
• [Journal Article] ゲノムワイド関連解析 (GWAS) による腹腔鏡補助下大腸切除術後フェンタニル必要量に影響する遺伝子多型の同定 (2017)
  • Author(s): 西澤大輔, 三枝勉, 辻田美紀, 天野功二郎, 田代浄, 石井利昌, 山口茂樹, 笠井慎也, 長谷川準子, 池田和隆, 北村晶, 林田眞和
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 37(2) Pages: 53-54
• [Journal Article] 遺伝子多型に基づいた個別鎮痛法の開発 (2017)
  • Author(s): 西澤大輔, 福田謙一, 林田眞和, 池田和隆
  • Journal Title: ペインクリニック Volume: 38
• [Journal Article] Association between UGT2B7 gene polymorphisms and fentanyl sensitivity in patients undergoing painful orthognathic surgery (2016)
  • Author(s): Muraoka W, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Wajima K, Nakagawa T, Ikeda K
  • Journal Title: Mol Pain Volume: 12 Pages: 1-12
  • DOI: 10.1177/1744806916683182
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Opposite associations between the rs3845446 single-nucleotide polymorphism of the CACNA1E gene and postoperative pain-related phenotypes in gastrointestinal surgery versus previously reported orthognathic surgery (2016)
  • Author(s): Amano K, Nishizawa D, Mieda T, Tsujita M, Kitamura A, Hasegawa J, Inada E, Hayashida M, Ikeda K
  • Journal Title: J Pain Volume: 17(10) Pages: 1126-1134
  • DOI: 10.1016/j.jpain.2016.07.001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Nociceptin/orphanin FQ receptor gene variation is associated with smoking status in Japanese (2016)
  • Author(s): Kasai S, Nishizawa D, Hasegawa J, Sato N, Tanioka F, Sugimura H, Ikeda K
  • Journal Title: Pharmacogenomics Volume: 17(13) Pages: 1441-1451
  • DOI: 10.2217/pgs.15.184
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] KCNJ6 (GIRK2) 遺伝子rs2835859多型と術後鎮痛、疼痛感受性、及びニコチン依存との関連 (2016)
  • Author(s): 西澤大輔, 福田謙一, 笠井慎也, 大谷保和, 長谷川準子, 佐藤直美, 山田英孝, 谷岡書彦, 椙村春彦, 林田眞和, 池田和隆
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 36 Pages: 115-116
• [Journal Article] オピオイド感受性遺伝子の個体差について (2016)
  • Author(s): 西澤大輔, 福田謙一, 林田眞和, 池田和隆
  • Journal Title: Locomotive Pain Frontier Vol. 5 No.2: Volume: 5 Pages: 14-18
  • NAID: 40021039483
• [Journal Article] Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy (2016)
  • Author(s): Mieda T*, Nishizawa D*, Nakagawa H, Tsujita M, Imanishi H, Terao K, Yoshikawa H, Itoh K, Amano K, Tashiro J, Ishii T, Ariyama J, Yamaguchi S, Kasai S, Hasegawa J, Ikeda K, Kitamura A, Hayashida M (*: These authors contributed equally to this study.)
  • Journal Title: Pharmacogenomics Volume: 17 Pages: 133-145
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 疼痛緩和における”テーラーメイド治療”の実現に向けて (2016)
  • Author(s): 井手聡一郎, 吉田香織, 西澤大輔, 福田謙一, 池田和隆
  • Journal Title: 医薬ジャーナル Volume: 52 Pages: 151-155
• [Journal Article] 遺伝子多型が麻酔科の臨床にもたらすもの（遺伝子多型を利用した麻酔科臨床への応用） (2016)
  • Author(s): 吉田香織, 井手聡一郎, 西澤大輔, 池田和隆, 福田謙一
  • Journal Title: A net Volume: 20 Pages: 11-14
• [Journal Article] Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies (2015)
  • Author(s): Nishizawa D et al.
  • Journal Title: Molecular Brain Volume: 8 Pages: 50-50
  • DOI: 10.1186/s13041-015-0142-x
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association between AKT1 Gene Polymorphism rs2498794 and Smoking-Related Traits with reference to Cancer Susceptibility. (2015)
  • Author(s): Nishizawa, D., Kasai, S., Hasegawa, J., Sato，N., Tanioka, F., Sugimura, H., Ikeda, K. and Dobashi, Y.
  • Journal Title: Biomed Res Int. Volume: 2015.94. Pages: 316829-316829
  • DOI: 10.1155/2015/316829
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements (2015)
  • Author(s): Aoki Y, Nishizawa D, Hasegawa J, Kasai S, Yoshida K, Koukita Y, Ichinohe T, Nagashima M, Katoh R, Satoh Y, Tagami M, Hayashida M, Fukuda K, Ikeda K.
  • Journal Title: J Pharmacol Sci Volume: 127 Pages: 391-393
  • DOI: 10.1016/j.jphs.2015.02.005
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 痛みの遺伝子多型についての基礎研究と臨床研究 (2015)
  • Author(s): 西澤大輔, 福田謙一, 林田眞和, 池田和隆
  • Journal Title: 麻酔 Volume: 64
• [Journal Article] 物質依存症と遺伝子多型 (2015)
  • Author(s): 西澤大輔, 池田和隆
  • Journal Title: 日本臨牀 Volume: 73 Pages: 1465-1472
• [Journal Article] ゲノムワイド及び追加関連解析によるニコチン依存関連遺伝子多型の同定 (2015)
  • Author(s): 西澤大輔, 笠井慎也, 長谷川準子, 佐藤直美, 谷岡書彦, 長島誠, 氏家寛, 橋本亮太, 田中雅嗣, 椙村春彦, 池田和隆
  • Journal Title: 日本神経精神薬理学雑誌 Volume: 35 Pages: 45-46
• [Journal Article] Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses (2015)
  • Author(s): Yoshida K, Nishizawa D, Ichinomiya T, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Journal Title: PLoS ONE Volume: 10
  • DOI: 10.1371/journal.pone.0116885
  • NAID: 120005694850
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl (2014)
  • Author(s): Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Minami M, Ikeda K.
  • Journal Title: Mol Pain Volume: 10 Pages: 75-75
  • DOI: 10.1186/1744-8069-10-75
  • NAID: 120005549601
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Association Between <i>KCNJ6</i> (<i>GIRK2</i>) Gene Polymorphism rs2835859 and Post-operative Analgesia, Pain Sensitivity, and Nicotine Dependence (2014)
  • Author(s): Nishizawa D, Fukuda K, Kasai S, Ogai Y, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Hayashida M, Ikeda K.
  • Journal Title: J Pharmacol Sci Volume: 126 Issue: 3 Pages: 253-263
  • DOI: 10.1254/jphs.14189FP
  • NAID: 130004700283
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 痛みと遺伝子多型 (2014)
  • Author(s): 西澤大輔, 池田和隆
  • Journal Title: 痛みのマネジメントupdate－基礎知識から緩和ケアまで－日本医師会雑誌 Volume: 143
• [Journal Article] 多様な依存性物質の作用に共通して影響する遺伝子多型 (2014)
  • Author(s): 西澤大輔, 池田和隆
  • Journal Title: 日本アルコール・薬物医学会雑誌 Volume: 49 Pages: 83-91
  • Peer Reviewed
• [Presentation] 薬理学的解析支援 (2018)
  • Author(s): 森屋由紀, 西澤大輔, 井手聡一郎, 池田和隆
  • Organizer: 平成29年度新学術領域研究 学術研究支援基盤形成【先端モデル動物支援プラットフォーム】成果発表会
• [Presentation] ゲノムワイド関連解析（GWAS）による腹腔鏡補助下大腸切除術中レミフェンタニル投与速度に寄与する遺伝子多型の同定 (2018)
  • Author(s): 西澤大輔, 三枝勉, 辻田美紀, 中川秀之, 山口茂樹, 笠井慎也, 長谷川準子, 福田謙一, 北村晶, 林田眞和, 池田和隆
  • Organizer: 平成29年度新学術領域研究 学術研究支援基盤形成【先端モデル動物支援プラットフォーム】成果発表会
• [Presentation] ゲノムワイド関連解析（GWAS）による慢性疼痛感受性遺伝子多型の同定 (2017)
  • Author(s): 西澤大輔, 有田英子, 花岡一雄, 矢島直, 井関雅子, 加藤実, 小川節郎, 平沼彩子, 笠井慎也, 長谷川準子, 林田眞和, 池田和隆
  • Organizer: 日本人類遺伝学会第62回大会
• [Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil requirements during laparoscopic-assisted colectomy (2017)
  • Author(s): Nishizawa D, Mieda T, Tsujita M, Nakagawa H, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K
  • Organizer: The American Society of Human Genetics 67th Annual Meeting
  • Int'l Joint Research
• [Presentation] インターロイキン-17A の一塩基多型と痛み関連表現型との関連解析 (2017)
  • Author(s): 大岡静衣, 西澤大輔, 長谷川準子, 高橋香央里, 中山京子, 江畑裕子, 福田謙一, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] 日本人における N-methyl-D-aspartate receptor 2B subunit 遺伝子多型とアルコール依存症との関連研究 (2017)
  • Author(s): 成田心, 吉原英児, 西澤大輔, 川合厚子, 池田和隆, 岩橋和彦
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] ゲノムワイド関連解析（GWAS）による腹腔鏡補助下大腸切除術中レミフェンタニル投与速度に影響する遺伝子多型の同定 (2017)
  • Author(s): 西澤大輔, 三枝勉, 辻田美紀, 山口茂樹, 笠井慎也, 長谷川準子, 福田謙一, 北村晶, 林田眞和, 池田和隆
  • Organizer: 第39回日本生物学的精神医学会・第47回日本神経精神薬理学会 合同年会
• [Presentation] Association study of a candidate genetic variant with the development of taxane-induced peripheral neuropathy (2017)
  • Author(s): Tanabe Y, Nishizawa D, Hasegawa J, Ikeda K, Shimomura A, Takano T, Shimizu C
  • Organizer: 第15回日本臨床腫瘍学会学術集会
• [Presentation] 遺伝子多型と疼痛感受性・オピオイド感受性 (2017)
  • Author(s): 林田眞和, 福田謙一, 西澤大輔, 池田和隆
  • Organizer: 日本麻酔科学会第64回学術集会
• [Presentation] 疼痛緩和における“テーラーメイド治療”の実現に向けて (2017)
  • Author(s): 井手聡一郎, 髙橋香央里, 西澤大輔, 福田謙一, 池田和隆
  • Organizer: 第11回日本緩和医療薬学会年会
  • Invited
• [Presentation] Genetic polymorphisms in the orexin system (focusing on a polymorphism associated with nicotine dependence) (2017)
  • Author(s): Nishizawa D, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research / Invited
• [Presentation] Association between genetic polymorphisms in Cav2.3 (R-type) Ca2+ channels and fentanyl sensitivity in patients undergoing painful cosmetic surgery (2017)
  • Author(s): Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Associations between polymorphisms close to the cAMP responsive element binding protein 1 (CREB1) gene and the activating transcription factor 2 (ATF2) gene and fentanyl sensitivity (2017)
  • Author(s): Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Single nucleotide polymorphisms in the 5’flanking region of interleukin-17A gene significantly associate with pain sensitivity (2017)
  • Author(s): Ohka S, Nishizawa D, Hasegawa J, Takahashi K, Nakayama K, Ebata Y, Fukuda K, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Association of Proopioimeranocortin gene polymorphism with vulnerability to alcohol dependence in Japanese (2017)
  • Author(s): Kasai S, Nishizawa D, Higuchi S, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil infusion rate in patients undergoing laparoscopic-assisted colectomy (2017)
  • Author(s): Nishizawa D, Mieda T, Tsujita M, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K
  • Organizer: 5th Congress of Asian College of Neuropsychopharmacology (AsCNP 2017)
  • Int'l Joint Research
• [Presentation] 薬物感受性及び疾患脆弱性に関する全ゲノム関連解析結果データベースからのデータ抽出支援 (2017)
  • Author(s): 西澤大輔, 福田謙一, 林田眞和, 椙村春彦, 清水千佳子, 田中雅嗣, 池田和隆
  • Organizer: 平成28年度新学術領域研究 学術研究支援基盤形成 【先端モデル動物支援プラットフォーム】 成果発表会
  • Place of Presentation: 琵琶湖ホテル（滋賀県・大津市）
  • Year and Date: 2017-02-07
• [Presentation] ゲノムワイド関連解析を利用したオピオイドのテーラーメイド医療への試み (2016)
  • Author(s): 三枝勉, 西澤大輔, 北村晶, 福田謙一, 池田和隆, 林田眞和
  • Organizer: 第34回日本麻酔・集中治療テクノロジー学会学術集会
  • Place of Presentation: ハイアット・リージェンシー東京（東京都・新宿区）
  • Year and Date: 2016-11-26
• [Presentation] Genetic mechanisms underlying individual differences in sensitivity to pain and opioids (2016)
  • Author(s): Ikeda K, Nishizawa D, Hayashida M, Fukuda K
  • Organizer: 16th World Congress on Pain
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-09-27
  • Int'l Joint Research / Invited
• [Presentation] Genome-wide association study identifies candidate loci associated with intraoperative remifentanil infusion rate in patients undergoing laparoscopic-assisted colectomy (2016)
  • Author(s): Nishizawa D, Mieda T, Tsujita M, Yamaguchi S, Kasai S, Hasegawa J, Fukuda K, Kitamura A, Hayashida M, Ikeda K
  • Organizer: 16th World Congress on Pain
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-09-27
  • Int'l Joint Research
• [Presentation] 鎮痛薬感受性と関連するオピオイドペプチド遺伝子多型の解析 (2016)
  • Author(s): 笠井慎也, 西澤大輔, 林田眞和, 長島誠, 加藤良二, 池田和隆
  • Organizer: 第3回包括的緩和医療科学学術研究会・第4回Tokyo疼痛緩和次世代研究会 合同研究会
  • Place of Presentation: TKPガーデンシティ永田町（東京都・千代田区）
  • Year and Date: 2016-08-28
• [Presentation] Cav2.3(R型)電位依存性Ca2+チャネル遺伝子多型と鎮痛薬感受性との関連 (2016)
  • Author(s): 井手総一郎, 西澤大輔, 福田謙一, 笠井慎也, 長谷川準子, 林田眞和, 池田和隆
  • Organizer: 第36回鎮痛薬・オピオイドペプチドシンポジウム
  • Place of Presentation: 北海道大学（北海道・札幌市）
  • Year and Date: 2016-08-20
• [Presentation] タバコ・ニコチン依存に影響を及ぼすオピオイド受容体関連遺伝子 (2016)
  • Author(s): 笠井慎也, 西澤大輔, 佐藤直美, 谷岡書彦, 椙村春彦, 池田和隆
  • Organizer: 第36回鎮痛薬・オピオイドペプチドシンポジウム
  • Place of Presentation: 北海道大学（北海道・札幌市）
  • Year and Date: 2016-08-20
• [Presentation] Prediction formulas for individual opioid analgesic requirements based on genetic polymorphism analyses (2016)
  • Author(s): Nishizawa D, Yoshida K, Ichinomiya T, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Organizer: The International Narcotics Research Conference 2016
  • Place of Presentation: Bath（UK）
  • Year and Date: 2016-07-14
  • Int'l Joint Research
• [Presentation] オピオイド感受性関連遺伝子多型の同定とその臨床応用 (2016)
  • Author(s): 西澤大輔
  • Organizer: 日本ペインクリニック学会第50回大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-07-08
  • Invited
• [Presentation] オピオイド感受性関連遺伝子多型の同定とテーラーメイド疼痛治療の開始 (2016)
  • Author(s): 池田和隆, 西澤大輔, 福田謙一, 林田眞和
  • Organizer: 日本ペインクリニック学会第50回大会
  • Place of Presentation: パシフィコ横浜（神奈川県・横浜市）
  • Year and Date: 2016-07-08
  • Invited
• [Presentation] Genome-wide association study identifies candidate loci associated with postoperative fentanyl requirements after laparoscopic-assisted colectomy (2016)
  • Author(s): Nishizawa D, Mieda T, Nakagawa H, Tsujita M, Imanishi H, Terao K, Yoshikawa H, Itoh K, Amano K, Tashiro J, Ishii T, Ariyama J, Yamaguchi S, Kasai S, Hasegawa J, Ikeda K, Kitamura A, Hayashida M
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul（Korea）
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Opposite associations between the rs3845446 single-nucleotide polymorphism of the CACNA1E gene and postoperative pain-related phenotypes in gastrointestinal surgery versus previously reported orthognathic surgery (2016)
  • Author(s): Amano K, Nishizawa D, Mieda T, Tsujita M, Kitamura A, Hasegawa J, Inada E, Hayashida M, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul（Korea）
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Association between the rs7583431 single-nucleotide polymorphism close to the activating transcription factor 2 (ATF2) gene and the analgesic effect of fentanyl in the preoperative cold pressor-induced pain test (2016)
  • Author(s): Aoki Y, Nishizawa D, Yoshida K, Hasegawa J, Kasai S, Takahashi K, Koukita Y, Ichinohe T, Hayashida M, Fukuda K, Ikeda K
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul（Korea）
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] Genetic polymorphisms commonly associated with sensitivity to addictive substances (2016)
  • Author(s): Ikeda K, Nishizawa D, Fukuda K, Hayashida M, Higuchi S, Sugimura H, Sora I
  • Organizer: 30th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Seoul（Korea）
  • Year and Date: 2016-07-04
  • Int'l Joint Research / Invited
• [Presentation] Activating transcription factor 2(ATF2)遺伝子近傍の遺伝子多型rs7583431と冷水誘発疼痛試験におけるフェンタニルの鎮痛効果との関連 (2016)
  • Author(s): 青木謙典, 西澤大輔, 吉田香織, 長谷川準子, 笠井慎也, 髙橋香央里, 髙北義彦, 一戸達也, 林田眞和, 福田謙一, 池田和隆
  • Organizer: 第46回日本神経精神薬理学会年会(JSNP)
  • Place of Presentation: Seoul（Korea）
  • Year and Date: 2016-07-03
• [Presentation] ゲノムワイド関連解析（GWAS）による腹腔鏡補助下大腸切除術後フェンタニル必要量に影響する遺伝子多型の同定 (2016)
  • Author(s): 西澤大輔, 三枝勉, 中川秀之, 辻田美紀, 今西宏和, 寺尾和久, 吉川博昭, 伊藤一志, 天野功二郎, 田代浄, 石井利昌, 有山淳, 山口茂樹, 笠井慎也, 長谷川準子, 中山京子, 江畑裕子, 池田和隆, 北村晶, 林田眞和
  • Organizer: 第46回日本神経精神薬理学会年会(JSNP)
  • Place of Presentation: Seoul（Korea）
  • Year and Date: 2016-07-02
• [Presentation] オピオイド不適切使用の評価と中止法において遺伝子検査が貢献する可能性 (2016)
  • Author(s): 池田和隆, 西澤大輔, 林田眞和, 福田謙一
  • Organizer: 第21回日本緩和医療学会学術大会
  • Place of Presentation: 国立京都国際会館・グランドプリンスホテル京都（京都府・京都市）
  • Year and Date: 2016-07-02
  • Invited
• [Presentation] Genome-wide association study identifies a potent locus associated with human opioid sensitivity (2015)
  • Author(s): Nishizawa D, Ikeda K
  • Organizer: 4th Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-22
  • Int'l Joint Research / Invited
• [Presentation] Association between the rs1465040 single-nucleotide polymorphism close to the transient receptor potential subfamily C member 3 (TRPC3) gene and postoperative analgesic requirements (2015)
  • Author(s): Aoki Y, Nishizawa D, Hasegawa J, Kasai S, Yoshida K, Koukita Y, Ichinohe T, Nagashima M, Katoh R, Satoh Y, Tagami M, Hayashida M, Fukuda K, Ikeda K
  • Organizer: 4th Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-20
  • Int'l Joint Research
• [Presentation] Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and postoperative analgesia, pain sensitivity, and nicotine dependence (2015)
  • Author(s): Nishizawa D, Fukuda K, Kasai S, Ogai Y, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Hayashida M, Ikeda K
  • Organizer: 4th Congress of Asian College of Neuropsychopharmacology
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2015-11-20
  • Int'l Joint Research
• [Presentation] Association between KCNJ6 (GIRK2) gene polymorphism rs2835859 and postoperative analgesia, pain sensitivity, and nicotine dependence (2015)
  • Author(s): Nishizawa D, Fukuda K, Kasai S, Ogai Y, Hasegawa J, Sato N, Yamada H, Tanioka F, Sugimura H, Hayashida M, Ikeda K
  • Organizer: The American Society of Human Genetics 65th Annual Meeting
  • Place of Presentation: Baltimore, USA
  • Year and Date: 2015-10-08
  • Int'l Joint Research
• [Presentation] ゲノムワイド関連解析（GWAS）によるオピオイド感受性関連遺伝子多型の同定とその臨床応用 (2015)
  • Author(s): 西澤大輔, 池田和隆
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: タワーホール船堀（東京都・江戸川区）
  • Year and Date: 2015-09-26
  • Invited
• [Presentation] ATP受容体P2X7サブタイプ遺伝子多型と疼痛及び鎮痛薬感受性との相関 (2015)
  • Author(s): 井手聡一郎, 西澤大輔, 福田謙一, 笠井慎也, 長谷川準子, 林田眞和, 南雅文, 池田和隆
  • Organizer: 第45回日本神経精神薬理学会・第37回日本生物学的精神医学会合同年会
  • Place of Presentation: タワーホール船堀（東京都・江戸川区）
  • Year and Date: 2015-09-24
• [Presentation] GIRK channel as a candidate target for pharmacotherapy of drug and alcohol dependence (2015)
  • Author(s): Ikeda K, Sugaya N, Ogai Y, Nishizawa D
  • Organizer: 4th APSAAR / 5th IDARS Conference
  • Place of Presentation: Sydney, Australia
  • Year and Date: 2015-08-19
  • Int'l Joint Research
• [Presentation] Genetic mechanisms underlying individual differences in opioid sensitivity in Japanese (2015)
  • Author(s): Ikeda K, Nishizawa D, Hayashida M, Fukuda K
  • Organizer: WPA Regional Congress OSAKA Japan 2015
  • Place of Presentation: 大阪府立国際会議場（大阪府・大阪市）
  • Year and Date: 2015-06-05
  • Int'l Joint Research
• [Presentation] R型電位依存性カルシウムチャネル遺伝子の一塩基多型rs3845446は、内臓性炎症性疼痛の有無により、体性炎症性疼痛に対する術後鎮痛薬必要量に相反する影響を与える (2015)
  • Author(s): 天野功二郎, 三枝勉, 北村晶, 西澤大輔, 池田和隆, 林田眞和
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸ポートピアホテル・神戸国際展示場（兵庫県・神戸市）
  • Year and Date: 2015-05-28
• [Presentation] ラミニンbeta3遺伝子 (LAMB3) の一塩基多型rs2076222は、腹腔鏡補助下大腸切除術後のPCAフェンタニル必要量に影響する (2015)
  • Author(s): 林田眞和, 三枝勉, 西澤大輔, 池田和隆, 有山淳, 北村晶
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸ポートピアホテル・神戸国際展示場（兵庫県・神戸市）
  • Year and Date: 2015-05-28
• [Presentation] 疼痛感受性やオピオイド感受性に影響を及ぼす遺伝子多型 (2015)
  • Author(s): 林田眞和, 福田謙一, 西澤大輔, 池田和隆
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸ポートピアホテル・神戸国際展示場（兵庫県・神戸市）
  • Year and Date: 2015-05-28
• [Presentation] 遺伝子多型判定に基づくオピオイド性鎮痛薬必要量予測式の構築と検証 (2015)
  • Author(s): 吉田香織, 福田謙一, 林田眞和, 西澤大輔, 池田和隆, 一戸達也
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸ポートピアホテル・神戸国際展示場（兵庫県・神戸市）
  • Year and Date: 2015-05-28
• [Presentation] Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy (2014)
  • Author(s): Nishizawa D, Kobayashi D, Takasaki Y, Kasai S, Aoki Y, Hasegawa J, Kakizawa T, Ikeda K, Fukuda K
  • Organizer: The American Society of Human Genetics 64th Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2014-10-19
• [Presentation] ゲノムワイド関連解析によるオレキシン2受容体遺伝子多型Val308Ileとニコチン依存との関連の同定 (2014)
  • Author(s): 西澤大輔, 笠井慎也, 佐藤直美, 谷岡書彦, 長島誠, 氏家寛, 橋本亮太, 田中雅嗣, 椙村春彦, 池田和隆
  • Organizer: 平成26年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: パシフィコ横浜, 横浜
  • Year and Date: 2014-10-03
• [Presentation] PCLO SNP rs13438494 regulates DA and 5-HT uptake, accompanied with splicing efficiency and dependence-like behaviors in genomic association studies (2014)
  • Author(s): Uno K, Nishizawa D, Seo S, Sasaki N, Ohi K, Nabeshima T, Hashimoto R, Ozaki N, Ikeda K, Miyamoto Y, Nitta A
  • Organizer: 29th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-06-24
• [Presentation] Associations of an orexin (hypocretin) receptor 2 gene polymorphism with nicotine dependence found in genome-wide and following association studies (2014)
  • Author(s): Nishizawa D, Kasai S, Hasegawa J, Sato N, Tanioka F, Nagashima M, Ujike H, Hashimoto R, Tanaka M, Sugimura H, Ikeda K
  • Organizer: 29th CINP World Congress of Neuropsychopharmacology
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 2014-06-23
• [Presentation] Personalized pain control (2014)
  • Author(s): Ikeda K, Nishizawa D, Hayashida M, Fukuda K
  • Organizer: 2014 YONSEI BK21 PLUS-IGAKUKEN Joint Symposium
  • Place of Presentation: Soul, Korea
  • Year and Date: 2014-06-20
• [Book] Chapter 3: Pharmacology and pathophysiology. In: Addiction Medicine (Second Edition) (2016)
  • Author(s): Nishizawa D, Ikeda K
  • Total Pages: 672
  • Publisher: OXFORD UNIVERSITY PRESS
• [Book] Genome-wide association studies and human opioid sensitivity. In: The Neuropathology of Drug Addictions and Substance Misuse. Volume 1(VR Preedy, Ed) (2016)
  • Author(s): Nishizawa D, Ikeda K
  • Total Pages: 1132
  • Publisher: Academic Press
• [Book] Chapter 3: Pharmacology and pathophysiology. In: Addiction Medicine (Second Edition) (2016)
  • Author(s): Nishizawa D, Ikeda K
  • Publisher: UK: OXFORD UNIVERSITY PRESS
• [Book] Genome-wide association studies and human opioid sensitivity. In: The Neuropathology of Drug Addictions and Substance Misuse (2016)
  • Author(s): Nishizawa D, Ikeda K
  • Publisher: Waltham: Academic Press
• [Remarks] 公益財団法人東京都医学総合研究所「依存性薬物プロジェクトホームページ」
  • URL: http://www.igakuken.or.jp/abuse/index.html