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Prenatal nicotine exposure and inflammation in adulthood affect to tryptophan metabolites and aggravate psychiatric disorders.

Research Project

Project/Area Number 26860368
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Laboratory medicine
Research InstitutionDoshisha University (2015-2016)
Kyoto University (2014)

Principal Investigator

Murakami Yuki  同志社大学, 研究開発推進機構, 助教 (50580106)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsトリプトファン / ニコチン / 抑うつ / 慢性炎症
Outline of Final Research Achievements

It is not clarified how nicotine exposure during the pregnancy, and then inflammation in adulthood affect behaviors of offspring. In this study, we examined the influence of nicotine exposure during embryonic period (E14-P0) and inflammation induced by IFN-gamma; gene transfection in adulthood on the changes of tryptophan (TRP) metabolites and depression like behavior. We found that embryonic nicotine exposure affected changing TRP metabolites concentrations in serum, especially kynurenic acid (KA), which is antagonist of alpha7nicotinic acetylcholine receptor. We also found nicotine exposure during the embryonic period and inflammation in adulthood exacerbated depression like behavior and anxiety. In conclusion, our results suggest that nicotine in embryonic period affected TRP metabolites and caused imbalance of TRP metabolites. And nicotine exposure during the neuronal development and inflammation in adulthood might be related with onset of psychiatric disorders.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2017 2016 2015 2014

All Journal Article (7 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Acknowledgement Compliant: 3 results,  Open Access: 5 results) Presentation (6 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (2 results)

  • [Journal Article] Kynurenine 3-monooxygenase is implicated in antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions2017

    • Author(s)
      Tashiro T , Murakami Y , Mouri A , Imamura Y, Nabeshima T, Yamamoto, Y , Saito, K
    • Journal Title

      BEHAVIOURAL BRAIN RESEARCH

      Volume: 317 Pages: 279-285

    • DOI

      10.1016/j.bbr.2016.09.050

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Effect of Histone Acetylation on N-Methyl-D-Aspartate 2B Receptor Subunits and Interleukin-1 Receptors in Association with Nociception-Related Somatosensory Cortex Dysfunction in A Mouse Model of Sepsis2016

    • Author(s)
      Yukio Imamura, Nao Yoshikawa, Yuki Murkami, Satoko Mitani, Naoya Matsumoto,Hisatake Matsumoto, Tomoki Yamada, Kazuma Yamakawa, Junichiro Nakagawa, Hiroshi Ogura, Takeshi Shimazu, Takashi Jin
    • Journal Title

      Shock

      Volume: 45(6) Issue: 6 Pages: 660-667

    • DOI

      10.1097/shk.0000000000000547

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1.2016

    • Author(s)
      Murakami Y, Ishibashi T, Tomita E, Imamura Y, Tashiro T, Watcharanurak K, Nishikawa M, Takahashi Y, Takakura Y, Mitani S, Fujigaki H, Ohta Y, Kubo H, Mamiya T, Nabeshima T, Kim HC, Yamamoto Y, Saito K.
    • Journal Title

      SCIENTIFIC REPORTS

      Volume: 6 Issue: 1 Pages: 29920-29920

    • DOI

      10.1038/srep29920

    • NAID

      120006323748

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Gastro Jejunal Inner Lumen Bypass Device Inhibits the Growth of Pigs2016

    • Author(s)
      Hidetoshi Matsunami, Noriko Sasaki, Tomomi Yoshikawa, Masao Takemura, Kazuhiro Watanabe, Sanae Shibata, Mifumi Kawabe, Tatsuya Matsubara, Yuki Murakami, Makoto Hayashi
    • Journal Title

      Journal of Diabetic Complications & Medicine

      Volume: 1 Pages: 1-4

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel Portable Electroencephalograph for Monitoring Human Brain Activity Prior to Anxiety with Balloon Popping Stimuli2015

    • Author(s)
      Satoru Kubo, Yukio Imamura, Jun Imamura, Yoshio Yabe, Kazuhiko Kita, Toshio Igarashi, Yutaka Kanazawa, Tomoyuki Tashiro, Yuki Murakami, Satoko Mitani
    • Journal Title

      Horizon in Neuroscience Reseach

      Volume: 18 Pages: 1-13

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Continual Dynamics Of Prefrontal Oxyhemoglobin Patterns During Emotion And Feeling In Humans2015

    • Author(s)
      Yukio Imamura, Takashi Jin, Shota Hori, Natsuki Tsujita, Nao Yoshikawa, Yuki Murakami, Satoko Mitani, Keijiro Yamada, Akitoshi Seiyama, Huan Wang, Shoken Koh
    • Journal Title

      Journal of Multidisciplinary Engineering Science Studies

      Volume: 1 Pages: 6-11

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel Portable Electroencephalograph for Monitoring Human Brain Activity Prior to Anxiety with Balloon Popping Stimuli2015

    • Author(s)
      Satoru Kubo, Yukio Imamura, Jun Imamura, Yoshio Yabe, Kazuhiko Kita, Toshio Igarashi, Yutaka Kanazawa, Tomoyuki Tashiro, Yuki Murakami, Satoko Mitani
    • Journal Title

      Horizons in Neuroscience Research

      Volume: 18 Pages: 1-13

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 神経発達障害に関連した遺伝子欠損動物における行動解析とトリプトファン代謝の変化2016

    • Author(s)
      村上由希
    • Organizer
      第37回日本トリプトファン研究会
    • Place of Presentation
      東京農業大学(東京都世田谷区)
    • Year and Date
      2016-12-10
    • Related Report
      2016 Annual Research Report
  • [Presentation] Depressive symptoms, as a side effect of Interferon-alpha therapy induced by induction od indoleamine 2,3-dioxygenase 12016

    • Author(s)
      Yuki Murakami, Hyoung-Chun Kim, Toshitaka Nabeshima, Kuniaki Saito他5名
    • Organizer
      30th The International College of Neuropsychopharmacology
    • Place of Presentation
      ソウル(韓国)
    • Year and Date
      2016-07-03
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Depressive Symptoms, as a side effect of Interferon-alpha therapy induced by induction of indoleamine 2,3-dioxygenase 12016

    • Author(s)
      Yuki Murakami, Eiichi Tomita, Makiya Nishikawa, Akihiro Mouri, Hisako Kubo, Yasuko Yamamoto, Hyoung-Chun Kim, Toshitaka Nabeshima, Kuniaki Saito
    • Organizer
      The International College of Neuropsychopharmacology
    • Place of Presentation
      COEX, Koria
    • Year and Date
      2016-07-03
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 薬剤誘発性うつ病様病態におけるトリプトファン代謝の役割2015

    • Author(s)
      村上由希 斉藤邦明
    • Organizer
      第55回日本臨床化学会年次学術集会
    • Place of Presentation
      大阪大学コンベンションセンター
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Invited
  • [Presentation] 先制医療の実現に向けたバイオリソースバンクでのデータベース構築(第1報)2014

    • Author(s)
      竹田真由 加奈山憲代 桜井雅史 村上由希 山本康子 竹村正男 林慎 松波英寿 舩渡忠男 登勉 斉藤邦明
    • Organizer
      第61回臨床検査医学会学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2014-11-22 – 2014-11-25
    • Related Report
      2014 Research-status Report
  • [Presentation] 個別化先制医療の実現に向けたデータベースの構築2014

    • Author(s)
      村上由希 桜井雅史 斉藤邦明
    • Organizer
      第30回日本健康科学学会学術集会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2014-09-20 – 2014-09-21
    • Related Report
      2014 Research-status Report
  • [Book] Tryptophan Metabolism: Implications for Biological Processes, Health and Disease2015

    • Author(s)
      Yuki Murakami, Hiroyasu Ito, Kuniaki Saito
    • Total Pages
      377
    • Publisher
      Human Press
    • Related Report
      2015 Research-status Report
  • [Book] Tryptophan Metabolism: Implications for Biological Processes, Health and Disease2015

    • Author(s)
      Yuki Murakami, Hiroyasu Ito, Kuniaki Saito
    • Total Pages
      377
    • Publisher
      Humana Press
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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