Prenatal nicotine exposure and inflammation in adulthood affect to tryptophan metabolites and aggravate psychiatric disorders.
| Project/Area Number |
26860368
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Doshisha University (2015-2016)
Kyoto University (2014) |
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Principal Investigator |
Murakami Yuki 同志社大学, 研究開発推進機構, 助教 (50580106)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | トリプトファン / ニコチン / 抑うつ / 慢性炎症 |
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| Outline of Final Research Achievements |
It is not clarified how nicotine exposure during the pregnancy, and then inflammation in adulthood affect behaviors of offspring. In this study, we examined the influence of nicotine exposure during embryonic period (E14-P0) and inflammation induced by IFN-gamma; gene transfection in adulthood on the changes of tryptophan (TRP) metabolites and depression like behavior. We found that embryonic nicotine exposure affected changing TRP metabolites concentrations in serum, especially kynurenic acid (KA), which is antagonist of alpha7nicotinic acetylcholine receptor. We also found nicotine exposure during the embryonic period and inflammation in adulthood exacerbated depression like behavior and anxiety. In conclusion, our results suggest that nicotine in embryonic period affected TRP metabolites and caused imbalance of TRP metabolites. And nicotine exposure during the neuronal development and inflammation in adulthood might be related with onset of psychiatric disorders.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Effect of Histone Acetylation on N-Methyl-D-Aspartate 2B Receptor Subunits and Interleukin-1 Receptors in Association with Nociception-Related Somatosensory Cortex Dysfunction in A Mouse Model of Sepsis2016
Author(s)
Yukio Imamura, Nao Yoshikawa, Yuki Murkami, Satoko Mitani, Naoya Matsumoto,Hisatake Matsumoto, Tomoki Yamada, Kazuma Yamakawa, Junichiro Nakagawa, Hiroshi Ogura, Takeshi Shimazu, Takashi Jin
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Journal Title
Shock
Volume: 45(6)
Issue: 6
Pages: 660-667
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1.2016
Author(s)
Murakami Y, Ishibashi T, Tomita E, Imamura Y, Tashiro T, Watcharanurak K, Nishikawa M, Takahashi Y, Takakura Y, Mitani S, Fujigaki H, Ohta Y, Kubo H, Mamiya T, Nabeshima T, Kim HC, Yamamoto Y, Saito K.
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Journal Title
SCIENTIFIC REPORTS
Volume: 6
Issue: 1
Pages: 29920-29920
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Continual Dynamics Of Prefrontal Oxyhemoglobin Patterns During Emotion And Feeling In Humans2015
Author(s)
Yukio Imamura, Takashi Jin, Shota Hori, Natsuki Tsujita, Nao Yoshikawa, Yuki Murakami, Satoko Mitani, Keijiro Yamada, Akitoshi Seiyama, Huan Wang, Shoken Koh
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Journal Title
Journal of Multidisciplinary Engineering Science Studies
Volume: 1
Pages: 6-11
Related Report
Peer Reviewed / Open Access
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[Presentation] Depressive Symptoms, as a side effect of Interferon-alpha therapy induced by induction of indoleamine 2,3-dioxygenase 12016
Author(s)
Yuki Murakami, Eiichi Tomita, Makiya Nishikawa, Akihiro Mouri, Hisako Kubo, Yasuko Yamamoto, Hyoung-Chun Kim, Toshitaka Nabeshima, Kuniaki Saito
Organizer
The International College of Neuropsychopharmacology
Place of Presentation
COEX, Koria
Year and Date
2016-07-03
Related Report
Int'l Joint Research
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