| Project/Area Number |
26860374
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
Arito Mitsumi 聖マリアンナ医科大学, 医学部, 助教 (00509911)
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Kouhei 近畿大学, 生物理工学部, 講師 (70500578)
SATO Toshiyuki 聖マリアンナ医科大学, 医学部, 助教 (10350430)
KUROKAWA Manae 聖マリアンナ医科大学, 医学部, 大学院教授 (90301598)
SUEMATSU Naoya 聖マリアンナ医科大学, 医学部, 准教授 (50202122)
OKAMOTO Kazuki 聖マリアンナ医科大学, 医学部, 准教授 (40177085)
KATO Tomohiro 聖マリアンナ医科大学, 医学部, 教授 (80233807)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 全身性エリテマトーデス / SLE / スプライシング / 全身性エリテマトーテス |
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| Outline of Final Research Achievements |
It was studied whether‘measurement method of splicing activity of peripheral blood mononuclear cells (PBMCs)’is useful as a single diagnosis of systemic lupus erythematosus (SLE).
Firstly, the measurement method of splicing activity of PBMCs was developed and optimized. Next, the splicing activity of PBMCs from the patients with SLE and healthy donors was measeured by this methods. As a result of that, there was no difference on the splicing activity between groups of the patients with SLE and healthy donors. For a while, it was found that the measurement of splicing activity of only T cells may be more accurate than that of PBMCs, so I will investigate splicing activity of T cells from the patients with SLE and healthy donors.
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