The first step for elucidation of mechanism of asthma with eosinophilic chronic rhinosinusits and establishment of Airway Medicine

• Project/Area Number: 26860377
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Kansai Medical University
• Principal Investigator: KOBAYASHI Yoshiki 関西医科大学, 医学部, 講師 (10375298)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 好酸球性副鼻腔炎 / ステロイド抵抗性 / ホスファターゼ / 重症喘息 / 気管支喘息

Outline of Final Research Achievements

Eosinophilic chronic rhinosinusitis (ECRS) with asthma is known as refractory and recurrence-prone disease. In particular, ECRS patients with severe asthma had elevated levels of fractionated exhaled nitric oxide and reduced response to corticosteroids. Corticosteroid sensitivity was reduced in both bronchial epithelial cells located near inflammatory site and peripheral blood mononuclear cells. Impaired proteins (some phosphatases) involved in regulation of glucocorticoid receptor function may be one of mechanisms.

Research Products

• [Journal Article] Protein tyrosine phosphatase PTP-RR regulates corticosteroid sensitivity (2016)
  • Author(s): Kobayashi Y, Ito K, Kanda A, Tomoda K, Miller-Larsson A, Barnes PJ, Mercado N
  • Journal Title: Respiratory Research Volume: 17 Issue: 1 Pages: 30-30
  • DOI: 10.1186/s12931-016-0349-0
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Residual exhaled nitric oxide elevation in asthmatics is associated with eosinophilic chronic rhinosinusitis (2015)
  • Author(s): Kobayashi Y, Asako M, Ooka H, Kanda A, Tomoda K, Yasuba H
  • Journal Title: Journal of Asthma Volume: 52 Issue: 10 Pages: 1060-1064
  • DOI: 10.3109/02770903.2015.1054404
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 喘息合併好酸球性副鼻腔炎に対するAirway Medicineの実践 (2016)
  • Author(s): 小林良樹
  • Organizer: 第55回日本鼻科学会
  • Place of Presentation: 栃木県総合文化センター 栃木県宇都宮市
  • Year and Date: 2016-10-13
  • Invited
• [Presentation] 喘息合併難治性ECRSにおける局所治療効果の検証 (2015)
  • Author(s): 小林良樹
  • Organizer: アレルギー・好酸球研究会2015
  • Place of Presentation: 学術総合センター 東京都千代田区
  • Year and Date: 2015-10-24
• [Presentation] 好酸球性副鼻腔炎合併喘息へのpMDI吸入ステロイド経鼻呼出療法 (2015)
  • Author(s): 小林良樹
  • Organizer: 第3回日本耳鼻咽喉科感染症・エアロゾル学会総会・学術講演会
  • Place of Presentation: ライフォートホテル札幌 北海道札幌市
  • Year and Date: 2015-09-04
  • Invited
• [Presentation] 喘息合併ECRSに対する経鼻呼出療法における適正な呼吸条件の推算 (2015)
  • Author(s): 小林良樹
  • Organizer: 第64回日本アレルギー学会学術大会
  • Place of Presentation: グランドプリンスホテル新高輪 国際館パミール 東京都港区
  • Year and Date: 2015-05-26
• [Presentation] 喘息合併ECRSにおけるステロイド感受性の検討 (2015)
  • Author(s): 小林良樹
  • Organizer: 第64回日本アレルギー学会学術大会
  • Place of Presentation: グランドプリンスホテル新高輪（東京都港区）
  • Year and Date: 2015-05-26
• [Presentation] 治療抵抗性ECRSにおける全身性および局所性ステロイド感受性の検討 (2014)
  • Author(s): 小林良樹
  • Organizer: 第53回日本鼻科学会
  • Place of Presentation: グランフロント大阪（大阪市）
  • Year and Date: 2014-09-26
• [Presentation] 気管支喘息合併ECRSへの新しいアプローチ (2014)
  • Author(s): 小林良樹
  • Organizer: 第53回日本鼻科学会
  • Place of Presentation: グランフロント大阪（大阪市）
  • Year and Date: 2014-09-25
  • Invited