The first step for elucidation of mechanism of asthma with eosinophilic chronic rhinosinusits and establishment of Airway Medicine
| Project/Area Number |
26860377
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Laboratory medicine
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| Research Institution | Kansai Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 好酸球性副鼻腔炎 / ステロイド抵抗性 / ホスファターゼ / 重症喘息 / 気管支喘息 |
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| Outline of Final Research Achievements |
Eosinophilic chronic rhinosinusitis (ECRS) with asthma is known as refractory and recurrence-prone disease. In particular, ECRS patients with severe asthma had elevated levels of fractionated exhaled nitric oxide and reduced response to corticosteroids. Corticosteroid sensitivity was reduced in both bronchial epithelial cells located near inflammatory site and peripheral blood mononuclear cells. Impaired proteins (some phosphatases) involved in regulation of glucocorticoid receptor function may be one of mechanisms.
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Report
(3 results)
Research Products
(9 results)
