Stress modified nociceptive responses in the anterior cingulate neurons during estrous cycle in female rats

• Project/Area Number: 26860382
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pain science
• Research Institution: Nagasaki University
• Principal Investigator: YAMASHITA Hiromi 長崎大学, 医歯薬学総合研究科(歯学系), 助教 (50706174)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 帯状回 / 性周期 / 情動 / 侵害刺激 / 前帯状回 / 性差 / 拘束ストレス / 侵害受容性応答 / 電気生理

Outline of Final Research Achievements

The pain is the warning signal which tells danger for a living body, and I have the important role. A relation between a pain and a stress is watched in recent years. But there are a lot of unclear points for participation of a sexual cycle. So vagina sumea of a female rat was extracted, a sexual cycle was specified by Giemsa stain and an experiment was made. For 6 hours, a day a wire netting restriction stress was performed as a continuous stress load. After noxial stimulus used a pinch stimulus and analyzed a reply of the beltlike time of the time of noxial stimulus, it increased in a reply of excitability in estrus.

Research Products

• [Journal Article] Body site-dependent changes in pain threshold during the estrous cycle in rats. (2015)
  • Author(s): Hiromi Yamashita, Jorge L Zeredo, Mari Kimoto, Zenro Nihei, Izumi Asahina, Kei Kaida, Kazuo Toda
  • Journal Title: Psychology and Neuroscience Volume: 8(3) Pages: 414-422
  • Peer Reviewed
• [Journal Article] Anterior cingulate responses evoked by mechanical nociceptive stimulation in female rats (2014)
  • Author(s): Hiromi Yamashita, J.L Zeredo, Z. Nihei, K. Kaida, M. Kimoto, M. Umeda, I. Asahina, K. Toda
  • Journal Title: Acta Physiologica Volume: 211(suppl s697) Issue: s697 Pages: 147-147
  • DOI: 10.1111/apha.12362
  • Peer Reviewed
• [Journal Article] Suppresive effects of D-Glucosamine on the 5-HT sensitive nociceptive units in the rat tooth pulpal nerve. (2014)
  • Author(s): K. Kaida, H. Yamashita, K. Toda, Y. Hayashi
  • Journal Title: BioMed Research International Volume: 2014,Article ID 187989 Pages: 1-6
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Stress modified nociceptive responses in the anterior cingulate neurons during estrous cycle in female rats (2015)
  • Author(s): Hiromi Yamashita, Jorge L Zeredo, Zenro Nihei, Kei Kaida, Mari Kimoto, Kazuo Toda
  • Organizer: European Brain and Behaviour Society
  • Place of Presentation: Verona, Italy
  • Year and Date: 2015-09-12
  • Int'l Joint Research
• [Presentation] Anterior cingulate responses evoked by mechanical nociceptive stimulation in female rats (2014)
  • Author(s): Hiromi Yamashita, J.L Zeredo, Z. Nihei, K. Kaida, M. Kimoto, M. Umeda, I. Asahina, K. Toda
  • Organizer: Federation of European Physiological Societies
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2014-08-27 – 2014-08-30
• [Presentation] Acupuncuture modifies neuronal activities in the nucleus reticularis lateralis in rats (2014)
  • Author(s): K. Toda, J.L. Zeredo, K. Moritaka, H. Yamashita, K. Kaida, M.S. Ota M. Kimoto
  • Organizer: Federation of European Physiological Societies
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2014-08-27 – 2014-08-30
• [Presentation] Stress-induced modulation of ileal motility in Capsici fructus-fed female rats (2014)
  • Author(s): M. Kimoto, J.L. Zeredo, Z. Nihei, M.S. Ota, H. Yamashita, K. Kaida, K. Toda
  • Organizer: Federation of European Physiological Societies
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2014-08-27