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New tachykinin receptor mediates pruriceptive processing in the spinal cord

Research Project

Project/Area Number 26860384
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pain science
Research InstitutionUniversity of Miyazaki

Principal Investigator

Nakayama-Naono Rumi  宮崎大学, 医学部, 特別研究員 (00609034)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords痒み / 痛み / 脊髄 / オーファン受容体 / サブスタンスP / 受容体 / 神経ペプチド / GPR83
Outline of Final Research Achievements

Tachykinin peptides represented by substance P (SP) share common amino acid sequences at the C-terminal end, F-X-G-L-M, an essential amino acids motif for their wide physiological functions. Whereas the functions of hemokinin-1 (HK-1), a new tachykinin peptide may work as a neurotransmitter as well as SP, but the details of its functions are still unclear.
We previously showed that HK-1 may play a critical role in itch transduction and the HK-1-preferred receptor may mediate itch signal in the spinal dorsal horn. Recently we found HK-1-preferred receptor based on amino acid homology to SP receptor, NK1R. Here we aim to clarify the involvement of HK-1-preferred receptor in itch processing mediated by HK-1.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2017 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Acknowledgement Compliant: 3 results,  Open Access: 2 results) Presentation (6 results) (of which Int'l Joint Research: 3 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] Distribution of hemokinin-1 in the rat trigeminal ganglion and2017

    • Author(s)
      K. Igawa, H. Funahashi, Y. Miyahara, R. Naono-Nakayama, H. Matsuo, Y. Yamashita, S. Sakodaa, T. Nishimori,Y. Ishida
    • Journal Title

      Archives of Oral Biology

      Volume: 79 Pages: 62-69

    • DOI

      10.1016/j.archoralbio.2017.03.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hemokinin-1-derived peptides have antipruritic effects in rats.2015

    • Author(s)
      H. Funahashi, R.Naono-Nakayama, G. Koganemaru, Y. Miyahara, T. Nishimori, K. Takamiya, Y. Ishida
    • Journal Title

      Therapeutic Targets for Neurological Diseases

      Volume: 2 Pages: 1-4

    • DOI

      10.14800/ttnd.704

    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hemokinin-1 mediates pruriceptive processing in the rat spinal cord.2014

    • Author(s)
      H. Funahashi, R.Naono-Nakayama, K. Ebihara, G. Koganemaru, A. Kuramashi, T. Ikeda,T. Nishimori, Y. Ishida
    • Journal Title

      Neuroscience

      Volume: 277 Pages: 206-216

    • DOI

      10.1016/j.neuroscience.2014.07.001

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] New tachykinin receptor mediates pruricepitive pricessing in the spinal cord2016

    • Author(s)
      R. Nakayama-Naono, H. Funahashi, Y. Miyahara, T. Nishimori, K. Takamiya
    • Organizer
      第16回 国際疼痛学会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New tachykinin receptor mediates pruriceptive processing in the spinal cord2016

    • Author(s)
      R. Naono-Nakayama
    • Organizer
      The 3rd International Symposium on Glyco-Neuroscience
    • Place of Presentation
      兵庫県、淡路島
    • Year and Date
      2016-01-14
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] Orphan receptor GPR83 mediates pruriceptive processing in the spinal cord2015

    • Author(s)
      R. Naono-Nakayama, H. Funahashi,, K. Takamiya, T. Nishimori.
    • Organizer
      8th World congress on itch
    • Place of Presentation
      奈良県、奈良市
    • Year and Date
      2015-09-25
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] ヘモキニンー1フラグメントペプチドHK-1(1-5)が痒み伝達を抑制する2015

    • Author(s)
      中山-直野 留美、船橋 英樹、西森 利數、髙宮 考悟
    • Organizer
      第37回 日本疼痛学会
    • Place of Presentation
      熊本県、熊本市
    • Year and Date
      2015-07-04
    • Related Report
      2015 Research-status Report
  • [Presentation] Hemokinin-1 (1-5) elicits the inhibitory effect on pruritic processing.2014

    • Author(s)
      R. Naono-Nakayama, H. Funahashi,, K. Takamiya, T. Nishimori.
    • Organizer
      Society for Neuroscience 2014
    • Place of Presentation
      ワシントン(米国)
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] An amino-terminal fragment of Hemokinin-1 has an inhibitory effect on pruritic processing in rats.2014

    • Author(s)
      R. Naono-Nakayama, H. Funahashi,, K. Takamiya, T. Nishimori.
    • Organizer
      第 37 回 日本神経科学会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Patent(Industrial Property Rights)] ヘモキニン-1受容体及びヘモキニン-1由来ペプチド2015

    • Inventor(s)
      中山留美, 西森利數
    • Industrial Property Rights Holder
      中山留美, 西森利數
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-08-11
    • Related Report
      2015 Research-status Report
    • Overseas

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Published: 2014-04-04   Modified: 2018-03-22  

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