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The roles of glycosphingolipids in neuropathic pain.

Research Project

Project/Area Number 26860385
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pain science
Research InstitutionKitasato University

Principal Investigator

Watanabe Shun  北里大学, 薬学部, 助教 (50415337)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsスフィンゴ脂質 / ガングリオシド / 疼痛 / 鎮痛 / 糖脂質 / シアル酸
Outline of Final Research Achievements

Gangliosides that are sialic acid containing-glycosphingolipids are abundant in neural tissues and previous studies revealed important roles in neuronal functions. However, the roles of gangliosides in pain sensing remain unclear. We reported that gangliosides induced hyperalgesia via glutamate signaling in skin tissues. Thus, we investigated gangliosides composition in neuropathic pain and inflammatory pain models. Complex gangliosides were increased in skin tissues from inflammatory pain model mice. Furthermore, intraplantar injection of sialidase which cleave sialyl residues of glycoconjugates including gangliosides reduced mechanical allodynia caused by inflammation. These findings suggested that gangliosides are involved in mechanical allodynia in inflammatory pain.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results)

  • [Journal Article] Gangliosides and nociception2015

    • Author(s)
      渡辺俊、田辺光男
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 145 Issue: 4 Pages: 216-218

    • DOI

      10.1254/fpj.145.216

    • NAID

      130005061550

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pain Signaling and Gangliosides2015

    • Author(s)
      Watanabe S, Higashi H
    • Journal Title

      Trends in Glycoscience and Glycotechnology

      Volume: 27 Issue: 154 Pages: 37-45

    • DOI

      10.4052/tigg.1311.1

    • NAID

      130005061795

    • ISSN
      0915-7352, 1883-2113
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] The changes of glycosphingolipids during inflammatory pain.2016

    • Author(s)
      渡辺 俊 , 高野 香奈子 , 佐川 眞美、岩井 孝志 , 松尾(池田) 由理 , 内藤 康仁 , 田辺 光男
    • Organizer
      第89回 日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜 会議センター (神奈川県横浜市)
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 疼痛における糖脂質の関与2015

    • Author(s)
      渡辺 俊, 田辺 光男
    • Organizer
      痛み研究会2015「痛みの理解を目指した先端的アプローチ」
    • Place of Presentation
      岡崎カンファレンスセンター(愛知県岡崎市)
    • Year and Date
      2015-12-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] 炎症性疼痛におけるシアリダーゼによる鎮痛効果の検討2015

    • Author(s)
      渡辺 俊 , 高野 香奈子 , 岩井 孝志 , 松尾(池田) 由理 , 内藤 康仁 , 田辺 光男
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 疼痛に関与する糖脂質2015

    • Author(s)
      渡辺 俊、 田辺 光男
    • Organizer
      第88回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Research-status Report
  • [Presentation] 糖脂質ガングリオシドによる痛覚過敏の惹起2014

    • Author(s)
      渡辺 俊、東 秀好、田辺 光男
    • Organizer
      第36回日本疼痛学会
    • Place of Presentation
      KKRホテル大阪(大阪府大阪市)
    • Year and Date
      2014-06-20 – 2014-06-21
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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