The roles of glycosphingolipids in neuropathic pain.
Project/Area Number |
26860385
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pain science
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Research Institution | Kitasato University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | スフィンゴ脂質 / ガングリオシド / 疼痛 / 鎮痛 / 糖脂質 / シアル酸 |
Outline of Final Research Achievements |
Gangliosides that are sialic acid containing-glycosphingolipids are abundant in neural tissues and previous studies revealed important roles in neuronal functions. However, the roles of gangliosides in pain sensing remain unclear. We reported that gangliosides induced hyperalgesia via glutamate signaling in skin tissues. Thus, we investigated gangliosides composition in neuropathic pain and inflammatory pain models. Complex gangliosides were increased in skin tissues from inflammatory pain model mice. Furthermore, intraplantar injection of sialidase which cleave sialyl residues of glycoconjugates including gangliosides reduced mechanical allodynia caused by inflammation. These findings suggested that gangliosides are involved in mechanical allodynia in inflammatory pain.
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Report
(3 results)
Research Products
(7 results)
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[Presentation] 炎症性疼痛におけるシアリダーゼによる鎮痛効果の検討2015
Author(s)
渡辺 俊 , 高野 香奈子 , 岩井 孝志 , 松尾(池田) 由理 , 内藤 康仁 , 田辺 光男
Organizer
BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
Place of Presentation
神戸ポートアイランド(兵庫県神戸市)
Year and Date
2015-12-01
Related Report
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[Presentation] 疼痛に関与する糖脂質2015
Author(s)
渡辺 俊、 田辺 光男
Organizer
第88回日本薬理学会年会
Place of Presentation
名古屋国際会議場(愛知県名古屋市)
Year and Date
2015-03-18 – 2015-03-20
Related Report
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