| Project/Area Number |
26860392
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | National Institute of Occupational Safety and Health, Japan |
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Principal Investigator |
Suzuki Ken-ichiro 独立行政法人労働安全衛生総合研究所, その他部局等, 研究員 (30548384)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | X線 / PET / 金ナノ粒子 / がん / リン脂質 / 体内動態 / ナノ粒子 / 治療 / 脳 / グリア / 血液脳関門 / ＰＥＴ |
|---|
| Outline of Final Research Achievements |
Gold nanoparticles are useful for the development of cancer radiotherapy. Moreover, it has been shown that the modifications of gold nanoparticle surfaces are common approach to improve the radiotherapy enhancement. Therefore, future study for novel modification of gold nanoparticle surfaces should be focus on. However, the relationship between nanoparticle surface modification and exact effects for uptake of nanoparticles in the cancer cells or distribution of nanoparticles in the body remains unclear. In this study, we constructed specific four different typed phospholipid-adsorbed gold nanoparticles and demonstrated their uptake in the cancer cells and their distribution in the mouse body. From of our results, we expect that the phospholipid-modified gold nanoparticles will lead to key advances for human applications in the cancer radiotherapy.
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