| Project/Area Number |
26860393
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical Physics and Radiological Technology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | glioma / nanoparticles / radiotherapy / radiodiagnosis / BNCT / gold nanoparticles / boron-hyaluronic acid / neutron capture therapy / photon capture therapy |
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| Outline of Final Research Achievements |
We evaluated the feasibility of hyaluronic acid (HA) to be used as targeting agent for boron compounds, including gold nanoparticles (GNPs), for combined glioma radiotherapy. Boron-HA (BHA) showed different accumulation in tumor and healthy tissues in rats. Security of BHA bonds might be necessary to increase the stability of the compound. We evaluated the efficacy of boron-neutron capture therapy using boron-phenylalanine (BPA) with GNPs used for absorbed neutron dose estimation at the accelerator-based neutron source. Our method allows to determine the absorbed neutron dose using combined boron compounds containing high-Z element and can be implemented in isotope scanning and positron emission tomography (PET).
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