Novel adjuvant method of malignant brain tumor diagnosis and therapy with targeted nanoparticles made of high-Z elements
Project/Area Number |
26860393
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Medical Physics and Radiological Technology
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Research Institution | University of Tsukuba |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Keywords | glioma / nanoparticles / radiotherapy / radiodiagnosis / BNCT / gold nanoparticles / boron-hyaluronic acid / neutron capture therapy / photon capture therapy |
Outline of Final Research Achievements |
We evaluated the feasibility of hyaluronic acid (HA) to be used as targeting agent for boron compounds, including gold nanoparticles (GNPs), for combined glioma radiotherapy. Boron-HA (BHA) showed different accumulation in tumor and healthy tissues in rats. Security of BHA bonds might be necessary to increase the stability of the compound. We evaluated the efficacy of boron-neutron capture therapy using boron-phenylalanine (BPA) with GNPs used for absorbed neutron dose estimation at the accelerator-based neutron source. Our method allows to determine the absorbed neutron dose using combined boron compounds containing high-Z element and can be implemented in isotope scanning and positron emission tomography (PET).
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Report
(3 results)
Research Products
(17 results)
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[Presentation] Hyaluronic acid-melanin based boron-gold nanoparticles for combined neutron capture therapy and absorbed dose evaluation2015
Author(s)
Alexander Zaboronok, Sergey Taskaev, Sergej Uspenskii, Tetsuya Yamamoto, Kei Nakai, Mikhail Selyanin, Evgeniya Svidchenko, Nikolay Surin, Alexander Zelenetskii, Akira Matsumura
Organizer
8th Young Researchers BNCT Meeting
Place of Presentation
Pavia, Italy
Year and Date
2015-09-10
Related Report
Int'l Joint Research
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[Presentation] Hyaluronic Acid-based Nanomaterials for Combined Boron Neutron-Photon Capture Therapy2015
Author(s)
Alexander Zaboronok, Kei Nakai, Tetsuya Yamamoto, Sergej Uspenskii, Fumiyo Yoshida, Mikhail Selyanin, Evgeniya Svidchenko, Nikolay Surin, Alexander Zalenetskii, Akira Matsumura
Organizer
The 15th International Congress of Radiation Research (ICRR 2015)
Place of Presentation
Kyoto International Conference Center, Kyoto, Japan
Year and Date
2015-05-25
Related Report
Int'l Joint Research
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