Development of fast dose calculation algorithm by deterministic calculation method optimized for boron neutron capture therapy

• Project/Area Number: 26860394
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical Physics and Radiological Technology
• Research Institution: University of Tsukuba
• Principal Investigator: TAKADA Kenta 筑波大学, 医学医療系, 助教 (10640782)
• Research Collaborator: KUMADA Hiroaki ; SAKAE Takeji
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: BNCT / 線量評価 / 高速演算 / Monte Carlo method / ホウ素中性子捕捉療法 / 線量計算アルゴリズム / 高速計算 / 線量計算

Outline of Final Research Achievements

In this study, a new calculation program using diffusion theory for Boron Neutron Capture Therapy (BNCT) was developed. This calculation program succeeded faster calculation of the spatial distribution for neutron flux within the homogeneous phantom compared with the conventional Monte Carlo method. In addition, conversion factors for calculating the various doses from neutron fluxes were also prepared, and the conversion into various doses required for BNCT was also realized. The calculation program was improved so that the dose calculation on CT image basis can be performed assuming the actual treatment planning for BNCT. As a result, spatial distribution for neutron fluxes and doses using the head phantom were also successful.
The program developed in this research is capable of high speed calculation of neutron fluxes and various doses for BNCT as compared with the conventional Monte Carlo method, and it is expected that it can be utilized as a new calculation tool in the future.

Research Products

• [Journal Article] Development of Monte Carlo based real-time treatment planning system with fast calculation algorithm for boron neutron capture therapy (2016)
  • Author(s): Takada K, Kumada H, Liem PH, Sakurai H, Sakae T.
  • Journal Title: Phys Med Volume: 32 Issue: 12 Pages: 1846-1851
  • DOI: 10.1016/j.ejmp.2016.11.007
  • Peer Reviewed / Open Access
• [Presentation] Initiatives for the realization of fast calculations in the treatment planning of boron neutron capture therapy (2016)
  • Author(s): Kenta Takada, Hiroaki Kumada, Liem Peng Hong, Hideyuki Sakurai, Takeji Sakae
  • Organizer: 3rd Geant 4 Monte Carlo Workshop
  • Place of Presentation: University of Wollongong (Australia)
  • Year and Date: 2016-04-30
• [Presentation] Initiatives for the realization of fast calculations in the treatment planning of boron neutron capture therapy (2016)
  • Author(s): Kenta Takada
  • Organizer: 3rd Geant4 School & Monte Carlo Workshop for Radiotherapy, Imaging and Radiation Protection
  • Place of Presentation: Centre for Medical Radiation Physics, University of Wollongong, Australia
  • Year and Date: 2016-04-30
  • Int'l Joint Research