Development of variable spot size scanning irradiation

• Project/Area Number: 26860395
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical Physics and Radiological Technology
• Research Institution: Gunma University
• Principal Investigator: Souda Hikaru 群馬大学, 大学院医学系研究科, 助教 (30523162)
• Research Collaborator: FUJIMOTO Tetsuya ; KIKUCHI Haruka ; MAEYAMA Takuya ; KANO Yosuke
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 粒子線治療 / スキャニング照射 / 遅い取り出し / 可変ビームサイズ / 線量最適化計算 / ペナンブラ / 重粒子線治療 / スキャニング / ビームサイズ / ヒステリシス

Outline of Final Research Achievements

Variable spot size scanning irradiation method was developed for further concentrated dose distribution with sufficient flatness. Machine parameters were optimized for multiple beam size with stabilized beam positions. Irradiation plan was calculated by optimizing the parameters of particle number weights of multiple beam size and multiple beam spots. In the results of irradiation experiments, the dose flatness was kept within the tolerance for treatment and dose outside the target was clearly reduced. The proof of principle of variable spot size scanning irradiation was successfully achieved.

Research Products

• [Journal Article] Development of stereotactic radiosurgery using carbon beams (carbon-knife) (2018)
  • Author(s): Mintra Keawsamur, Akihiko Matsumura, Hikaru Souda, Yosuke Kano, Masami Torikoshi, Takashi Nakano and Tatsuaki Kanai
  • Journal Title: Physics in Medicine & Biology Volume: 63 Issue: 4 Pages: 045024-045024
  • DOI: 10.1088/1361-6560/aaaa4d
  • Peer Reviewed
• [Journal Article] Present Status of Gunma University Heavy Ion Medical Center (2017)
  • Author(s): Hikaru Souda, Haruka Kikuchi, Ken Yusa, Tashiro Mutsumi, Hirofumi Shimada, Akihiko Matsumura, Yoshiki Kubota, Tatsuaki Kanai, Masami Torikoshi
  • Journal Title: Proceedings of the 14th Annual Meeting of Particle Accelerator Society of Japan Volume: 1 Pages: 1425-1427
• [Journal Article] Improvement of Scanning Irradiation in Gunma University Heavy Ion Medical Center (2016)
  • Author(s): H. Souda, T. Fujimoto, H. Kikuchi, K. Torikai, K. Yusa, M. Tashiro, H. Shimada, A. Matsumura, Y. Kubota, S. Yamada, T. Kanai, M. Torikoshi, E. Takeshita
  • Journal Title: Proceedings of IPAC2016 Volume: - Pages: 1914-1916
  • Acknowledgement Compliant
• [Journal Article] Present Status of Gunma University Heavy Ion Medical Center (2016)
  • Author(s): Hikaru Souda, Haruka Kikuchi, Tetsuya Fujimoto, Ken Yusa, Mutsumi Tashiro, Hirofumi Shimada, Akihiko Matsumura, Yoshiki Kubota, Tatsuaki Kanai, Masami Torikoshi
  • Journal Title: Proceedings of the 13th Annual Meeting of Particle Accelerator Society of Japan Volume: - Pages: 1325-1327
  • Acknowledgement Compliant
• [Journal Article] Experiment of RF-Knock Out Extraction for High Precision Range Measurement (2016)
  • Author(s): Haruka Kikuchi, Hikaru Souda, Tastuaki Kanai, Yoshiyuki Hirano, Masami Torikoshi, Sung Hyun Lee, Kohei Osaki
  • Journal Title: Proceedings of the 13th Annual Meeting of Particle Accelerator Society of Japan Volume: - Pages: 182-186
• [Journal Article] Energy compensation of slow extracted beams with RF acceleration (2016)
  • Author(s): Tetsuya Fujimoto, Hikaru Souda, Masami Torikoshi, Tatsuaki Kanai, Satoru Yamada, Koji Noda
  • Journal Title: Nuclear Instruments and Methods in Physics Research A Volume: 812 Pages: 68-72
  • DOI: 10.1016/j.nima.2015.12.044
  • Peer Reviewed
• [Journal Article] PRESENT STATUS OF GUNMA UNIVERSITY HEAVY ION MEDICAL CENTER (2015)
  • Author(s): Hikaru Souda, Kota Torikai, Tetsuya Fujimoto, Ken Yusa, Mutsumi Tashiro, Hirofumi Shimada, Akihiko Matsumura, Yoshiki Kubota, Tatsuaki Kanai, Satoru Yamada, Masami Torikoshi,
  • Journal Title: Proceedings of 12th Annual Meeting of Particle Accelerator Society in Japan Volume: 12 Pages: 299-301
  • Acknowledgement Compliant
• [Journal Article] PRESENT STATUS OF GUNMA UNIVERSITY HEAVY ION MEDICAL CENTER (2014)
  • Author(s): Hikaru Souda, Tatsuaki Kanai, Satoru Yamada, Ken Yusa, Mutsumi Tashiro, Hirofumi Shimada, Yoshiki Kubota, Akihiko Matsumura, Akito Saito, Kota Torikai, Tetsuya Fujimoto, Masayuki Muramatsu, Atsushi Kitagawa, Eri Takeshita, Mitsutaka Kanazawa
  • Journal Title: Proceedings of the 11th Annual Meeting of Particle Accelerator Society of Japan Volume: 11 Pages: 324-326
  • Open Access / Acknowledgement Compliant
• [Journal Article] DEVELOPMENT OF SCANNING IRRADIATION IN GUNMA UNIVERSITY HEAVY ION MEDICAL CENTER (2014)
  • Author(s): Hikaru Souda, Tatsuaki Kanai, Satoru Yamada, Tetsuya Fujimoto, Yoshiki Kubota, Ken Yusa, Mutsumi Tashiro, Hirofumi Shimada, Akihiko Matsumura, Akito Saito, Kyohei Fukata, Kota Torikai, Eri Takeshita, Yosuke Kano, Kazushi Hanakawa, Yoshikazu Ishikawa, Yasuto Kishii, Taizo Honda, Yusuke Sakamoto
  • Journal Title: Proceedings of the 11th Annual Meeting of Particle Accelerator Society of Japan Volume: 11 Pages: 890-892
  • Open Access / Acknowledgement Compliant
• [Presentation] Compact Carbon Ion Accelerator: Operation achievement and Future Development (2018)
  • Author(s): Hikaru Souda
  • Organizer: Tsukuba Innovation Arena Symposium: The Next Generation of Hadron CancerTherapy and Its Beam Driver
  • Invited
• [Presentation] Evolution of Carbon Ion Therapy in Japan (2017)
  • Author(s): Hikaru Souda, Ken Yusa, Mutsumi Tashiro, Hirofumi Shimada, Akihiko Matsumura, Yoshiki Kubota, Kota Torikai, Tatsuaki Kanai, Masami Torikoshi
  • Organizer: Asian Forum for Accelerators and Detectors 2017
  • Place of Presentation: Lanzhou, China
  • Year and Date: 2017-01-16
  • Int'l Joint Research / Invited
• [Presentation] 群馬大学重粒子線医学センターの現状報告 (2017)
  • Author(s): 想田 光，菊池 遥，藤本 哲也，遊佐 顕，田代 睦，島田 博文，松村 彰彦，久保田 佳樹，金井 達明，取越 正己
  • Organizer: 第14回日本加速器学会年会
• [Presentation] Reliability of a Compact Carbon Ion Medical Accelerator (2017)
  • Author(s): H. Souda, K. Yusa, M. Tashiro, H. Shimada, A. Matsumura, Y. Kubota, E. Takeshita, S. Yamada, T. Kanai, M. Torikoshi
  • Organizer: Accelerator Reliability Workshop 2017
• [Presentation] Operation Performance of a Compact Carbon Ion Treatment Accelerator (2016)
  • Author(s): Hikaru Souda, Ken Yusa, Mutsumi Tashiro, Hirofumi Shimada, Akihiko Matsumura, Yoshiki Kubota, Eri Takeshita, Satoru Yamada, Tatsuaki Kanai, Masami Torikoshi
  • Organizer: Workshop of Accelerator Operations 2016
  • Place of Presentation: Shanghai, China
  • Year and Date: 2016-09-18
  • Int'l Joint Research
• [Presentation] Operation-Pattern Related Beam Fluctuation in a Heavy Ion Synchrotron (2016)
  • Author(s): Hikaru Souda, Ken Yusa, Mutsumi Tashiro, Hirofumi Shimada, Akihiko Matsumura, Yoshiki Kubota and Masami Torikoshi1
  • Organizer: 第112回日本医学物理学会学術大会
  • Place of Presentation: 沖縄コンベンションセンター(沖縄県宜野湾市)
  • Year and Date: 2016-09-08
• [Presentation] 群馬大学重粒子線医学センターの現状報告 (2016)
  • Author(s): 想田 光，菊池 遥，藤本 哲也，遊佐 顕，田代 睦，島田 博文，松村 彰彦，久保田 佳樹， 金井 達明，取越 正己
  • Organizer: 第13回日本加速器学会年会
  • Place of Presentation: 幕張メッセ(千葉県千葉市)
  • Year and Date: 2016-08-08
• [Presentation] 高精度飛程測定のためのRF-knock out 取り出し試験及びその評価 (2016)
  • Author(s): 菊池遥, 想田光, 金井達明 , 取越正己 , 平野祥之, Sung Hyun Lee , 大崎晃平
  • Organizer: 第13回日本加速器学会年会
  • Place of Presentation: 幕張メッセ(千葉県千葉市)
  • Year and Date: 2016-08-08
• [Presentation] Improvement of Scanning Irradiation in Gunma University Heavy Ion Medical Center (2016)
  • Author(s): H. Souda, T. Fujimoto, H. Kikuchi, K. Torikai, K. Yusa, M. Tashiro, H. Shimada, A. Matsumura, Y. Kubota, S. Yamada, T. Kanai, M. Torikoshi, E. Takeshita
  • Organizer: 7th International Particle Accelerator Conference
  • Place of Presentation: Busan, Korea
  • Year and Date: 2016-05-08
  • Int'l Joint Research
• [Presentation] Improvement of Scanning Irradiation in Gunma University Heavy Ion Medical Center (2016)
  • Author(s): Hikaru Souda, Tetsuya Fujimoto, Haruka Kikuchi, Kota Torikai, Ken Yusa, Mutsumi Tashiro, Hirofumi Shimada, Akihiko Matsumura, Yoshiki Kubota, Eri Takeshita, Satoru Yamada, Tatsuaki Kanai, Masami Torikoshi
  • Organizer: 7th International Particle Accelerator Conference (IPAC'16)
  • Place of Presentation: BEXCO, Busan, Korea
  • Year and Date: 2016-05-08
  • Int'l Joint Research
• [Presentation] ナノクレイフリッケゲル線量計による重粒子線の線量測定 (2015)
  • Author(s): 想田光、酒井真理、深田恭平、石居隆義、 前山拓哉、福西暢尚、石川顕一
  • Organizer: 第4回3次元ゲル線量計研究会
  • Place of Presentation: 帝京大学
  • Year and Date: 2015-11-28
• [Presentation] Dose Measurement of Scanning Irradiated Carbon Beam with the use of Gel Dosimeter (2015)
  • Author(s): Hikaru Souda, Makoto Sakai, Kyohei Fukata, Takayoshi Ishii, Takuya Maeyama,Nobuhisa Fukunishi, Kenichi L. Ishikawa
  • Organizer: 第110回日本医学物理学会学術大会
  • Place of Presentation: 北海道大学
  • Year and Date: 2015-09-18
• [Presentation] 群馬大学重粒子線医学センターの現状報告 (2015)
  • Author(s): 想田 光，鳥飼 幸太，藤本 哲也，遊佐 顕，田代 睦，島田 博文，松村 彰彦，久保田 佳樹，金井 達明，山田 聰，取越 正己，村松 正幸，北川 敦志，竹下 英里，金澤 光隆
  • Organizer: 第12回日本加速器学会年会
  • Place of Presentation: プラザ萬象・あいあいプラザ(福井県敦賀市)
  • Year and Date: 2015-08-05
• [Presentation] 群馬大学重粒子線医学センターの現状報告 (2014)
  • Author(s): 想田光、金井達明、山田聰、遊佐顕、田代睦、島田博文、久保田佳樹、松村彰彦、齋藤明登、鳥飼幸太、藤本哲也、村松正幸、北川敦志、竹下英里、金澤光隆
  • Organizer: 第11回日本加速器学会年会
  • Place of Presentation: 青森市・リンクステーションホール青森
  • Year and Date: 2014-08-09 – 2014-08-11
• [Presentation] 群馬大学重粒子線医学研究センターでのスキャニング照射開発 (2014)
  • Author(s): 想田光、金井達明、山田聰、藤本哲也,、久保田佳樹、遊佐顕、田代睦、島田博文、松村彰彦、齋藤明登、深田恭平、鳥飼幸太、竹下英里、加納洋介、花川和之、石川嘉一、岸井保人、本田泰三、坂本裕介
  • Organizer: 第11回日本加速器学会年会
  • Place of Presentation: 青森市・リンクステーションホール青森
  • Year and Date: 2014-08-09 – 2014-08-11
• [Presentation] DEVELOPMENT OF SCANNING IRRADIATION IN GUNMA UNIVERSITY HEAVY ION MEDICAL CENTER (2014)
  • Author(s): Hikaru Souda, Tatsuaki Kanai, Tetsuya Fujimoto, Kota Torikai, Yoshiki Kubota, Akihiko Matsumura, Hirofumi Shimada, Mutsumi Tashiro, Ken Yusa, Satoru Yamada, Eri Takeshita, Yosuke Kano, Kazushi Hanakawa, Yoshikazu Ishikawa, Yasuto Ando, Taizo Honda, Yusuke Sakamoto, Hisashi Harada, Katsuhisa Yoshida, Takashi Nakano
  • Organizer: 53rd Annual Meeting of Particle Therapy Co-Operating Group
  • Place of Presentation: 中国・上海
  • Year and Date: 2014-06-08 – 2014-06-14