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High accuracy calculation method of measuring tumor three-dimensional position on ultrasound images for radiotherapy with inspiratory breath hold

Research Project

Project/Area Number 26860396
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical Physics and Radiological Technology
Research InstitutionGunma University

Principal Investigator

Kubota Yoshiki  群馬大学, 重粒子線医学推進機構, 助教 (40583076)

Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords放射線治療 / 超音波 / 3次元追跡 / 呼吸同期照射 / 吸気 / 肝臓 / 金属マーカー / 金属マーカ / リピオドール / 座標系統合 / 呼吸同期 / 炭素線治療 / マーカ照合 / 超音波画像 / マーカ / 骨合わせ / X線 / 吸気息止め / 動体追跡 / 固定アーム / 処方線量 / 腫瘍合わせ / アーム
Outline of Final Research Achievements

Our method is based on the optical flow with extraction and tracking of feature points on two sectional ultrasound images. It was found that the error of our proposed method was 1.54±0.9 mm. For integrating the ultrasound coordinate with the room coordinate, it was found that it is difficult to achieve an accuracy < 1mm by existing inexpensive external camera systems. For clinical evaluation using metal marker near the tumor, CTV (clinical target volume) V95 (the percentage receiving ≧95% of the prescription dose) using the metal marker was 99.8±0.4 %, and V95 using bony structure was 94.0±7.5 %. It was found that using metal marker near the tumor improved the target dose largely.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (17 results)

All 2018 2017 2016 2014

All Journal Article (10 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results,  Open Access: 3 results,  Acknowledgement Compliant: 1 results) Presentation (7 results) (of which Int'l Joint Research: 4 results)

  • [Journal Article] Evaluation of the accuracy and clinical practicality of a calculation system for patient positional displacement in carbon ion radiotherapy at five sites2018

    • Author(s)
      Kubota Yoshiki、Hayashi Hayato、Abe Satoshi、Souda Saki、Okada Ryosuke、Ishii Takayoshi、Tashiro Mutsumi、Torikoshi Masami、Kanai Tatsuaki、Ohno Tatsuya、Nakano Takashi
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: 19 Issue: 2 Pages: 144-153

    • DOI

      10.1002/acm2.12261

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Robustness of patient positioning for interfractional error in carbon ion radiotherapy for stage I lung cancer: Bone matching versus tumor matching2017

    • Author(s)
      Sakai Makoto、Kubota Yoshiki、Saitoh Jun-ichi、Irie Daisuke、Shirai Katsuyuki、Okada Ryosuke、Torikoshi Masami、Ohno Tatsuya、Nakano Takashi
    • Journal Title

      Radiotherapy and Oncology

      Volume: - Issue: 1 Pages: 95-100

    • DOI

      10.1016/j.radonc.2017.10.003

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fiducial marker matching versus vertebral body matching: dosimetric impact of patient positioning in carbon ion radiotherapy for primary hepatic cancer2017

    • Author(s)
      Abe S, Kubota Y, Shibuya K, Koyama Y, Abe T, et al
    • Journal Title

      Physica Medica

      Volume: 33 Pages: 114-120

    • DOI

      10.1016/j.ejmp.2016.12.018

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Changes in Rectal Dose Due to Alterations in Beam Angles for Setup Uncertainty and Range Uncertainty in Carbon-Ion Radiotherapy for Prostate Cancer2016

    • Author(s)
      Yoshiki Kubota, Hidemasa Kawamura, Makoto Sakai, Ryou Tsumuraya, Mutsumi Tashiro, Ken Yusa, Nobuteru Kubo, Hiro Sato, Masahiro Kawahara, Hiroyuki Katoh, Tatsuaki Kanai, Tatsuya Ohno, Takashi Nakano
    • Journal Title

      PLOS ONE

      Volume: April Issue: 4 Pages: 1-11

    • DOI

      10.1371/journal.pone.0153894

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The impact of interfractional anatomical changes on the accumulated dose in carbon ion therapy of pancreatic cancer patients2016

    • Author(s)
      Houweling AC, Fukata K, Kubota Y, Shimada H, Rasch CR, et al.
    • Journal Title

      Radiotherapy and Oncology

      Volume: 119 Issue: 2 Pages: 319-25

    • DOI

      10.1016/j.radonc.2016.03.004

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 治療計画の現状について2016

    • Author(s)
      久保田佳樹, 遊佐顕
    • Journal Title

      放射線と産業

      Volume: 140 Pages: 4-7

    • Related Report
      2016 Research-status Report
  • [Journal Article] 放射線治療のための画像処理2016

    • Author(s)
      久保田佳樹
    • Journal Title

      画像ラボ

      Volume: 27 Pages: 12-17

    • NAID

      130006888507

    • Related Report
      2016 Research-status Report
  • [Journal Article] Verification of dose distribution in carbon ion radiotherapy for stage I lung cancer2016

    • Author(s)
      Irie D, Saitoh J, Shirai K, Abe T, Kubota Y, et al
    • Journal Title

      International Journal of Radiation Oncology Biology Phsics

      Volume: 96 Issue: 5 Pages: 1117-1236

    • DOI

      10.1016/j.ijrobp.2016.09.002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ガドリニウム造影剤が炭素線治療に及ぼす影響2016

    • Author(s)
      茂木 直, 酒井 真理, 岡田 良介, 板橋 佑典, 福島 康宏, 久保田佳樹, 他
    • Journal Title

      日本放射線技術学会雑誌

      Volume: 72 Issue: 12 Pages: 1230-1236

    • DOI

      10.6009/jjrt.2016_jsrt_72.12.1230

    • NAID

      130005251248

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] A new method for tracking organ motion on diagnostic ultrasound images2014

    • Author(s)
      Y Kubota, A Matsumura, M Fukahori, S Minohara, S Yasuda, H Nagahashi
    • Journal Title

      Medical Physics

      Volume: 41 Issue: 9 Pages: 092901-8

    • DOI

      10.1118/1.4892065

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Fiducial marker matching versus vertebral body matching: dosimetric impact of patient positioning in CIRT for primary hepatic cancer2017

    • Author(s)
      S Abe, Y Kubota, K Shibuya, T Abe, T Sutou, T Ohno, T Nakano
    • Organizer
      PTCOG56
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dosimetric effects of patient positioning method on the inter-fractional error in carbon ion radiotherapy for stage I lung cancer2017

    • Author(s)
      M Sakai, Y Kubota, J Saitoh, D Irie, K Shirai, R Okada, M Torikoshi, T Ohno, T Nakano
    • Organizer
      PTCOG56
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Customized mouthpiece in reducing tongue mucositis in carbon-ion radiotherapy for nasal tumors2017

    • Author(s)
      A Musya, J Saitoh, K Shirai, Y Kubota, H Shimada, T Abe, S Yokoo, T Ohno, T Nakano
    • Organizer
      PTCOG56
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ⅲ期肺癌の炭素線治療における腫瘍体積の経時的変化と腫瘍線量に与える影響2016

    • Author(s)
      大川原愛美, 久保田佳樹, 白井克幸, 岡田良介, 石居隆義, 須藤高行, 齋藤淳一, 大野達也, 中野隆史
    • Organizer
      日本放射線腫瘍学会第29回学術大会
    • Place of Presentation
      京都
    • Year and Date
      2016-11-25
    • Related Report
      2016 Research-status Report
  • [Presentation] Evaluation of hig-precision automatic patient positioning system with fast calculation in the carbon ion therapy; Patient study2016

    • Author(s)
      H Hayashi, Y Kubota, S Abe, S Souda, R Okada, T Ishii, M Tashiro, M Torikoshi, T Kanai, T Ohno, T Nakano
    • Organizer
      第111回日本医学物理学会学術大会
    • Place of Presentation
      横浜
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Presentation] 原発性肝癌の重粒子線治療に対する異なる位置照合法による腫瘍と正常肝の線量分布比較2016

    • Author(s)
      安部聖, 久保田佳樹, 渋谷圭, 阿部孝憲, 石居隆義, 須藤高行, 大野達也
    • Organizer
      第13回日本粒子線治療臨床研究会
    • Place of Presentation
      松本
    • Related Report
      2016 Research-status Report
  • [Presentation] Evaluation of High-Precision Automatic Patient Positioning System in Carbon Ion Radiotherapy: Patient study of 5 sites2016

    • Author(s)
      H Hayato, Y Kubota, S Abe, S Souda, R Okada, M Tashiro, M Torikoshi, T Kanai, T Ohno, T Nakano
    • Organizer
      The 3rd International Symposium of Gunma University Medical Innovation and the 8th International Conference on Advanced Micro- Device Engineering
    • Place of Presentation
      Kiryu
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2019-03-29  

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